专利号:WO-2022256490-A9 优先权日:2021-06-03 标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus 发明人:LOCKWOOD MARK 权利人:ANTIOS THERAPEUTICS INC 摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.
专利号:WO-2023039068-A1 优先权日:2021-09-08 标题:Compositions and methods for synthesis of peptide nucleic acid intermediates 发明人:COULL JAMES M; GILDEA BRIAN D 权利人:NEUBASE THERAPEUTICS INC 摘要:The present disclosure provides intermediates for the synthesis of peptide nucleic acid (PNA) backbones and monomers, such as cyclic intermediates, and methods of making the same.
专利号:US-6127489-A 优先权日:1996-05-20 标题:Silyl linker for solid phase organic synthesis of aryl-containing molecules 发明人:NEWLANDER KENNETH A; MOORE MICHAEL L 权利人:SMITHKLINE BEECHAM CORP 摘要:This invention relates to improved silyl linkers, methods for their preparation and their use in the solid phase synthesis of aromatic carbocycles, especially electron deficient aromatic carbocycles.
专利号:US-2023192731-A1 优先权日:2020-05-29 标 题 :Process for the stepwise synthesis of silahydrocarbons 发明人:AUNER NORBERT; STURM ALEXANDER G; SANTOWSKI TOBIAS; FELDER THORSTEN 权利人:MOMENTIVE PERFORMANCE MAT INC 摘要:The invention relates to a process for the stepwise synthesis of silahydrocarbons bearing up to four different organyl substituents at the silicon atom, wherein the process includes at least one step a) of producing a bifunctional hydridochlorosilane by a redistribution reaction, selective chlorination of hydridosilanes with an ether/HCl reagent, or by selective chlorination of hydridosilanes with SiCl 4 , at least one step b) of submitting a bifunctional hydridochloromonosilane to a hydrosilylation reaction, at least one step c) of hydrogenation of a chloromonosilane, and a step d) in which a silahydrocarbon compound is obtained in a hydrosilylation reaction.
专利号:US-2023109627-A1 优先权日:2019-11-14 标 题:Precursor chemistry for quantum dot synthesis enabling temperature-independent modulation of reactivity 发明人:HAN HEE-SUN; PARK JOONHYUCK 权利人:UNIV ILLINOIS 摘要:Provided herein are methods of making a high-quality quantum dot (QD), including by providing anion precursor chemistry that enables chemical modulation of precursor reactivity, thereby, allowing independent optimization of reaction temperature and precursor reactivity to systematically grow high quality QDs and by providing specially configured tunable precursors and related chemistry to facilitate separate reaction pathways for nucleation and growth, thereby accessing heat-up based synthesis of high-quality QD, including core-shell QDs. The methods may include providing a base-QD and a first anion or cation precursor having a composition comprising an anion or a cation element, respectively, and a modification agent. At least one add-layer is grown on the base-QD at a growth temperature, thereby making the high-quality QD comprising the base-QD and the at least one add-layer. At least one add-layer may have a composition comprising an add-layer cation element and an add-layer anion element.
专利号:US-12006324-B1 优先权日:2022-12-15 标题:Preparation method of trilaciclib and precursors of trilaciclib 发明人:KAMANI SATYANARAYANA; CHANG HSIN-YUN; LU TZU-CHIANG; MAI CHIN-CHENG 权利人:CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO LTD 摘要:Disclosed herein is a specific method of preparation of Trilaciclib. The said method is to provide an efficacy of a protection free synthetic method of Trilaciclib with less steps and good yields.
参考标题:Lewis Base Catalyzed Selective Chlorination Of Monosilanes 作者:Alexander G. Sturm,Julia I. Schweizer,Lioba Meyer,Tobias Santowski,Norbert Auner,Max C. Holthausen |发布日期:2018.12.3 摘要:A Preparatively Facile, Highly Selective Synthesis Of Bifunctional Monosilanes R2Sihcl, Rsihcl2 And Rsih2Cl Is Reported. By Chlorination Of R2Sih2 And Rsih3 With Concentrated Hcl/ether Solutions, The Stepwise Introduction Of Si−cl Bonds Is Readily Controlled By Temperature And Reaction Time For A Broad Range Of Substrates. In A Combined Experimental And Computational Study, We Establish A New Mode
合成参考文献
摘要:Pietruszka, J., Science of Synthesis, (2002) 4, 168.