CAS: 272-14-0; Thieno[3,2-C]Pyridine

相似化合物

94226-20-7 28783-23-5 94226-19-4

上下游产品

c]pyridinium; bromide5-(2-chloro-benzyl)-thieno[3,2-c]pyridinium; bromide thieno[3,2-c]pyridine-6-carboxylic acid N-(2,2-dimethoxyethyl)-4-methyl-N-3-(thienylmethyl)benzenesulfonamide c]pyridine5-(3-methyl-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine c]pyridine5-(3,5-dimethoxy-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine c]pyridine5-(2-methyl-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine c]pyridine5-(3,4-dichloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

📜4,5,6,7-四氢噻吩[3,2-C]吡啶盐酸盐置于水,Sodium Hydroxide,Manganese(Iv) Oxide体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 24.0H,以84.42%的收率获得噻吩并[3,2-C]吡啶
参考文献:一种噻吩并吡啶型离子棒状液晶,离子液体化合物的制备方法
标题:一种噻吩并吡啶型离子棒状液晶,离子液体化合物的制备方法
摘要:本发明公开了一种噻吩并吡啶型离子棒状液晶,离子液体化合物的制备方法,具有如通式ⅰ,通式ⅱ和通式ⅲ所示的结构.通式ⅰ所示的非对称化合物在一定温度范围内呈现液晶相,且可通过调控不同的无机离子,有机离子进行离子交换,一是使其能够在液晶相范围内实现介晶温度的按需收放,二是在离子液晶和离子液体间通过离子调控实现转换,为离子电池材料,特殊分子器件等的设计和应用提供了定向参考.通式ⅱ和通式ⅲ所示的化合物提供了噻吩并吡啶型棒状(离子)液晶(塑晶)化合物的另一种可能的设计及合成思路,这种制备方法合成路线较短,产率较高.

专利信息

专利号:EP-0439404-B1
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
发明人：KHATRI HIRALAL N; DEHOFF BRADLEY S
权利人:SANOFI SA
摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.

专利号:US-5068360-A
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno(3,2-C)pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5191090-A
优先权日:1990-01-25
标题:Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-4997945-A
优先权日:1990-01-25
标 题:Carbamate salts of 2-(2'-thienyl)alkylamines
发明人：KHATRI HIRALAL N
权利人:SYNTEX INC
摘要:The carbamate salt of 2-(2'-thienyl)-alkylamines and particularly the ethylamine and its method of synthesis are disclosed. The carbamate salt of 2-(2'-thienyl)ethylamine is a stable, easily transportable crystalline material that can be converted to 2-(2'-thienyl)ethylamine, a useful intermediate in the synthesis of 5[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine hydrochloride, also known as ticlopidine hydrochloride. The synthesis is carried out by reacting an amine of formula (I): (I) with CO2 in a hydrocarbon solvent to obtain the carbamate salt of formula II: II

专利号:WO-9946268-A1
优先权日:1998-03-12
标题 :MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
发明人：ANDERSEN HENRIK SUNE; JONES TODD KEVIN; HOLSWORTH DANIEL DALE
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2002019412-A1
优先权日:1998-03-12
标题:Modulators of protein tyrosine phosphatases (ptpases)
发明人：ANDERSEN HENRIK SUNE; JONES TODD KEVIN; HOLSWORTH DANIEL DALE
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.