相似化合物
41862-11-7 6642-31-5 21236-97-5物理性质
- 熔点300°C
- 沸点294.9±43.0 °C at 760 mmHg
- 闪点132.1±28.2 °C
- 密度1.6±0.1 g/cm3
- pKa:9.26±0.40(预测)
- PSA:80.88
- LogP:-1.3442
- 折射率1.663
- 蒸汽压0.0±1.4 mmHg at 25°C
- 溶解性Soluble In Diluted Sodium Hydroxide Solution.
- 敏感性常温常压下稳定,避免氧化物接触
- 外观形态白色至几乎白色粉末至晶体
- 储存条件请置于阴暗处, 惰性气氛中,室温
- 产品应用该化合物用于制作1,1-二甲基-1H-SPIRO[丙胺[4,5-B] QUINNOLINE-5,5,5--PYRROLO[2,3-D]]-2,2,4,46(1H,3H, 3H,7H,1H)-PENTAONE,通过在含有催化性P-甲苯磺酸的情况下与异氨酯发生反应.
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
4-Amino-2,6-dihydroxypyrimidine methyl p-toluene sulfonate dimethyl sulfate N-cyanoacetyl-N'-methyl-ureaN-cyanoacetyl-N'-methyl-urea H-pyrimidine-2,4-dione6-amino-1-methyl-5-phenylazo-1H-pyrimidine-2,4-dione 6-amino-1-methyl-3-propyl-1,3-dihydropyrimidine-2,4-dione 6-Amino-1,3-dimethylbarbituric acid 6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于双氧水体系中,化学反应生成6-氨基-1-甲基尿嘧啶
参考文献:Traube; Winter,Archiv Der Pharmazie,1906,Vol. 244,P. 13,15
标题:Traube; Winter,Archiv Der Pharmazie,1906,Vol. 244,P. 13,15
专利信息
专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人:HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.
专利号:WO-2015092739-A1
优先权日:2013-12-19
标题:Process for preparation of alogliptin
发明人:VADALI LAKSHMANA RAO; DASARI SRINIVASA RAO; MANUKONDA SESHADRI RAO; PONDURI RAJASEKHAR
权利人:MYLAN LAB LTD
摘要:Processes for the preparation of alogliptin benzoate are disclosed. The present disclosure also provides intermediates useful in the synthesis of alogliptin benzoate.
专利号:US-7521554-B2
优先权日:2001-11-09
标题 :A2B adenosine receptor antagonists
发明人:ELZEIN ELFATIH; KALLA RAO; MARQUART TIM; ZABLOCKI JEFF; LI XIAOFEN
权利人:CV THERAPEUTICS INC
摘要:Disclosed are processes for the synthesis of novel compounds that are A 2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.