CAS: 2432-12-4; 2,6-Dichloro-4-Methylphenol

上下游产品

CAS号106-44-5 对甲酚 | CAS号6640-27-3 2-氯-4-甲酚 | CAS号128-37-0 抗氧剂BHT | CAS号622-60-6 4-甲基苯乙醚 | CAS号6611-78-5 4-二氯甲基-4-甲基-2,5... | CAS号7732-18-5 水 | CAS号7782-50-5 氯气 | CAS号56-23-5 四氯化碳 | CAS号3337-59-5 3,5-二氯-4-羟基苯甲酸甲酯 | CAS号3336-41-2 3,5-二氯-4-羟基苯甲酸 | CAS号37908-97-7 3,5-二氯-4-甲氧基苯甲酸 | CAS号7731-29-5 trans-4-甲基环己醇 | CAS号7731-28-4 顺-4-甲基环己醇 | CAS号57018-04-9 甲基立枯磷 | CAS号2314-36-5 3,5-二氯-4-羟基苯甲醛 | CAS号6956-79-2 2,5-Cyclohexadi... | CAS号67341-33-7 1,3-dichloro-2-... | CAS号921630-64-0 2-(2,6-二氯-4-甲基-...

📜对甲酚置于sodium Hypochlorite体系中,用 水,乙腈 用作溶剂,以89%的收率获得2,6-二氯对甲酚
参考文献:通过催化对映体选择性加氢和哌啶中间体的差向异构化反应实用合成肾素抑制剂mk-1597(act-178882)
标题:通过催化对映体选择性加氢和哌啶中间体的差向异构化反应实用合成肾素抑制剂mk-1597(act-178882)
摘要:描述了实用的对映体选择性合成肾素抑制剂mk-1597(act-178882),这是一种潜在的高血压新疗法.合成路线以九个步骤提供了mk-1597,从商业上可获得的对甲酚(7)的总产率为29%.该序列的关键特征包括四取代烯酯的催化不对称氢化,高效的差向异构化/皂化序列4(可设置分子的两个立体中心)和胺片段2的短合成.
Doi:10.1021/jo102070E

专利信息

专利号:US-2012115907-A1
优先权日:2009-04-24
标题 :Novel compounds as inhibitors of renin
发明人：THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R
权利人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R; CADILA HEALTHCARE LTD
摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

专利号:EP-0830136-B1
优先权日:1995-03-07
标 题:New cryptophycins from synthesis
发明人：MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; HEMSCHEIDT THOMAS K; GOLAKOTI TRIMURTULU
权利人:UNIV HAWAII; UNIV WAYNE STATE
摘要:Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat neoplasia.

专利号:US-6013626-A
优先权日:1993-12-21
标题 :Cryptophycins from synthesis
发明人：MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; GOLAKOTI TRIMURTULU; HEMSCHEIDT THOMAS K
权利人:UNIV HAWAII; UNIV WAYNE STATE
摘要:A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.

专利号:US-4086423-A
优先权日:1973-10-12
标题 :Process for cephem synthesis
发明人：FIRESTONE RAYMOND A; RATCLIFFE RONALD W; CHRISTENSEN BURTON G
权利人:MERCK & CO INC
摘要:Cephalosporin antibiotics of the formula: ##STR1## are produced by cycloaddition of a glycine derivative of the formula ##STR2## with a thiazine derivative of the formula ##STR3##

专利号:US-4051132-A
优先权日:1974-01-23
标 题 :Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench
发明人：FIRESTONE RAYMOND A
权利人:MERCK & CO INC
摘要:Total synthesis methods employ 7-amino (6-amino in the case of a penicillin derivative) group in the alpha configuration. The instant invention provides a general route for preparing the 7β-amino (or 6β-amino) compound, through the formation of an imino-containing intermediate, followed by hydrolysis to the desired epimer. Novel intermediate products are provided. The compounds having the desired beta epimer can be converted to acylamino-antibiotics.

专利号:US-4167630-A
优先权日:1975-12-24
标 题 :Process for epimerizing beta-lactam antibiotic compounds, and related products
发明人：FIRESTONE RAYMOND A
权利人:MERCK & CO INC
摘要:Through total synthesis methods developed in the assignee's laboratories, new as well as old penicillin and cephalosporin compounds (all containing the beta-lactam functional group) have been prepared. One of the key intermediates prepared by total synthesis has the 7-amino (6-amino in the case of a penicillin derivative) group in the alpha configuration. The instant invention provides a general route for preparing the 7β-amino (or 6β-amino) compound, through the formation of an imino-containing intermediate, followed by hydrolysis to the desired epimer. Novel intermediate products are provided. The compounds having the desired beta epimer can be converted to acylaminoantibiotics.