专利号:WO-2025077857-A1 优先权日:2023-10-13 标题:Use of prmt5 inhibitor in treatment of tumors or cancers 发明人:YAO BING; GU XIAOHUI; MAO WEIFENG; ASWAD FRED JULLIEN; JOSEPH JAMES DAVID; LI MINGXI 权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD 摘要:The present disclosure describes a novel molecule having protein arginine methyltransferase 5 inhibitory activity, and methods for synthesis and use of a compound. Specifically, the present disclosure describes a compound of formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof, and methods for synthesis and use of the compound.
专利号:US-3957760-A 优先权日:1970-12-16 标 题:Amino acid derivatives 发明人:BODANSZKY MIKLOS 权利人:SQUIBB & SONS INC 摘要:New lactone intermediates useful in the synthesis of peptides are prepared by reacting an α-amino acid with an active carbonyl compound which forms a Schiff's base. The latter is treated with a condensing agent so that cyclization occurs and a lactone is formed from which a peptide may be produced by reaction with an amino acid ester and removal of the protecting groups.
专利号:US-2987525-A 优先权日:1958-10-29 标题:Synthesis of polycyclic heterocyclic compounds 发明人:ARRIGO JOSEPH T 权利人:UNIVERSAL OIL PROD CO
专利号:US-2018065917-A1 优先权日:2016-09-02 标 题 :Immune checkpoint inhibitors, compositions and methods thereof 发明人:WEBBER STEPHEN E; ALMASSY ROBERT J 权利人:POLARIS PHARMACEUTICALS INC 摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula (I) compounds R 1 , R 2 , X 1 , Y 1 and n are as defined in the specification. The inventive Formula (I) compounds are inhibitors of the PD-1/PD-L1 protein/protein binding or functional interaction and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer and infectious diseases.
专利号:CN-120157598-A 优先权日:2023-12-15 标 题 :Synthesis method of dihydrobenzofuran derivative
专利号:CN-117304067-A 优先权日:2022-06-21 标 题 :Synthesis method of non-nefardone intermediate 4-cyano-2-methoxybenzaldehyde