CAS: 2252403-56-6; 4-((S)-4-Acryloyl-2-Methylpiperazin-1-yl)-6-Fluoro-7-(2-Fluoro-6-Hydroxyphenyl)-1-(2-Isopropyl-4-Methylpyridin-3-yl)Pyrido[2,3-D]Pyrimidin-2(1H)-One

上下游产品

4,7-Dichloro-6-Fluoro-1-(2-Isopropyl-4-Methylpyridin-3-yl)Pyrido[2,3-D]Pyrimidin-2(1H)-One

2-氟-6-甲氧基苯硼酸置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,Potassium Acetate,三溴化硼,三氟乙酸,柠檬酸体系中,用 1,4-二氧六环,N-甲基吡咯烷酮,二氯甲烷,水,乙腈 用作溶剂,化学反应 5.0H,反应生成6-氟-7-(2-氟-6-羟基苯基)-1-[4-甲基-2-(1-甲基乙基)-3-吡啶基]-4-[(2S)-2-甲基-4-(1-氧代-2-丙烯-1-基)-1-哌嗪基]-吡啶并[2,3-D]嘧啶-2(1H)-酮
参考文献: Improved Synthesis Of Key Intermediate Of Kras G12C Inhibitor Compound[fr] Synthèse Améliorée D'Un Intermédiaire Clé Du Composé Inhibiteur De Kras G12C
标题: Improved Synthesis Of Key Intermediate Of Kras G12C Inhibitor Compound[fr] Synthèse Améliorée D'Un Intermédiaire Clé Du Composé Inhibiteur De Kras G12C
摘要:本发明涉及一种改进的,高效的,可扩展的过程,用于制备中间化合物,例如具有结构(i)的5M化合物,该化合物对于合成靶向kras G12C突变的化合物,如(II)是有用的.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2025115551-A1
优先权日:2023-10-03
标 题:Synthesis of ras inhibitors
发明人：LI YI; MENDOZA BENJAMIN; NAGANATHAN SRIRAM; WANG ROSS; YI YI; BALLMER STEVEN G; DAVIDSON JAMES; HUANG XIAOJUN
权利人:REVOLUTION MEDICINES INC
摘要:The present invention relates to Ras inhibitors, intermediates in the synthesis thereto, and methods for preparing the Ras inhibitors and the intermediates.

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:WO-2023143605-A1
优先权日:2022-01-31
标 题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents