专利号:US-3723437-A 优先权日:1970-09-15 标 题:4,10-(methaniminomethano phenanthrene derivatives 发明人:WIESNER K 权利人:AMERICAN HOME PROD 摘要:There are disclosed herein organic amines, and their pharmaceutically acceptable acid addition salts, which are 3,4,9,10-tetrahydro-6-methoxy-(2H)-4a,10-(methaniminomethano)phenanthren-2 -o1, 1,3,4,9,10,10a-hexahydro-6-methoxy-(2H)-4a,10(methaniminomethano) -phenanthren-2-o1,3,4,10,10a-tetrahydro-6methoxy-(9H)-4a,10 -(methaniminomethano)phenanthren-3-o1 and 1,2,3,4,9,10-hexahydro-3,6-dimethoxy- Alpha -methyl- Alpha alkyl-or aralkyl-3,10a-ethano-4a,10(methaniminomethano)phenanthrene-2-methanol and their corresponding N-(lower alkyl)derivatives. Process for the synthesis of these compound, which includes a facile preparation of the key intermediate, 3,4,9,10-tetrahydro-6-methoxy-12-methyl4a,10 -(methaniminomethano)phenanthrene-2,11(2H)-dione, is also disclosed. The amines possess analgesic, antibacterial and antifungal activities, and methods for their use are disclosed.
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