CAS: 2043-61-0; Cyclohexanecarboxaldehyde

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CAS号56698-00-1 Cyclohexancarbo... | CAS号1192-88-7 1-环己烯-1-甲醛 | CAS号201230-82-2 carbon monoxide | CAS号110-83-8 环己烯 | CAS号98-89-5 环己甲酸 | CAS号2719-27-9 环己甲酰氯 | CAS号100-49-2 环己基甲醇 | CAS号108-85-0 溴代环己烷 | CAS号80783-98-8 N-甲氧基-N-环己基甲酰胺 | CAS号5461-52-9 N,N-diethylcycl... | CAS号105550-66-1 2-cyclohexyl-5,... | CAS号100007-62-3 (R)-2-HYDROXY-2... | CAS号119-61-9 二苯甲酮 | CAS号1078726-20-1 1-Cyclohexyl-2,... | CAS号106115-44-0 2-(cyclohexylme... | CAS号3277-80-3 4-CHLOROPHENYL ... | CAS号492-41-1 去甲麻黄碱 | CAS号118888-19-0 (R)-3-cyclohexy...

亚甲基环己烷置于dimethyl Sulfide Borane,Pyridinium Chlorochromate体系中,化学反应生成环己烷基甲醛
参考文献:用于合成的有机硼烷.图4:用氯铬酸吡啶鎓氧化有机硼烷.通过氢硼化直接从末端烯烃合成醛
标题:用于合成的有机硼烷.图4:用氯铬酸吡啶鎓氧化有机硼烷.通过氢硼化直接从末端烯烃合成醛
摘要:在二氯甲烷中用氯铬酸吡啶鎓(pcc)氧化含伯烷基的三烷基硼烷,可得到相应的醛,收率很高.研究了用pcc氧化醇,硼酸酯和三烷基硼烷的化学计量.考虑到在用硼烷(bh 3 .Thf或bh 3 .Sme 2)进行硼氢化时,区域选择性差(仅94%的伯烷基)和对官能团的耐受性差),使用选择性更高的硼氢化剂双(3-甲基-2-丁基)硼烷(二亚甲基硼烷)从末端烯烃制备醛.但是,该方法的主要缺点是形成了副产物3-甲基-2-丁酮,每摩尔醛需要六摩尔的pcc.通过使用一氯硼烷-二甲基硫醚进行硼氢化可以避免这一困难.该试剂在末端烯烃的硼氢化反应中具有很高的区域选择性(约99%的伯烷基).水解后氧化所得的二烷基氯硼烷,以令人满意的收率获得所需的醛.因此,末端烯烃的加氢硼化,然后进行pcc氧化,是将烯烃转化为相应的醛的直接简便方法.
Doi:10.1016/s0040-4020(01)88154-0

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-4592874-A
优先权日:1980-05-14
标 题:Process for the synthesis of alpha-chlorinated chloroformates
发明人：CAGNON GUY C; PITEAU MARC D; SENET JEAN-PIERRE G; OLOFSON ROY A; MARTZ JONATHAN T
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:Process for the synthesis of alpha -chlorinated chloroformates, and new alpha -chlorinated chloroformates. The invention relates to a new process for the manufacture of alpha -chlorinated chloroformates and, to new alpha -chlorinated chloroformates as new industrial products. The process according to the invention consists of a synthesis, by catalytic phosgenation, of alpha -chlorinated chloroformates of the formula: in which: R represents a substituted or unsubstituted hydrocarbon radical and m represents an integer superior or equal to one, this synthesis consisting in reacting phosgene with the aldehyde R-CHO)m, in the presence of a catalyst which is an organic or inorganic substance which is capable in a medium containing an aldehyde of the formula R-CHO)m, phosgene and, possibly, a solvent, of generating a pair of ions one of which is an halogenide anion and the other is a cation which is sufficiently separated from said halogenide anion so as to give to the latter a nucleophilic power enabling it to react with the function(s) aldehyde of the molecule R-CHO)m.

专利号:WO-2023102600-A1
优先权日:2021-12-06
标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
发明人：ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
权利人:NEWSOUTH INNOVATIONS PTY LTD
摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.

专利号:US-8410320-B2
优先权日:2010-12-07
标 题 :Method for synthesis of secondary alcohols
发明人：CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI
权利人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI; NAT UNIV TSING HUA
摘要:A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.