CAS: 19853-09-9; 2-Phenylbenzylbromide

该化合物是一种溴化芳香化合物,通常用作有机合成的中间体,其主要优点包括作为苯基溴衍生物的活性,使其对核循环替代反应具有价值,特别是在形成碳-碳或碳-乙基环芳联结方面. 苯基替代物在保持活性的同时增强稳定性,允许在复杂的分子结构中进行受控的功能化.该化合物在用于建造双苯元素的制药和农用化学研究中特别有用,由于对水的敏感性,通常在惰性条件下处理.在高纯度情况下,2-苯基苯基苯基是先进的合成应用的多用途建筑块.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号2928-43-0 2-联苯基甲醇 | CAS号643-58-3 2-苯基甲苯 | CAS号16605-99-5 2-羧酸联苯甲酯 | CAS号1924-77-2 2-苯基苄胺 | CAS号24973-49-7 2-氰基联苯 | CAS号23533-35-9 2-biphenylylmag... | CAS号947-84-2 2-苯基苯甲酸 | CAS号19853-17-9 3-(2-phenylphen... | CAS号643-58-3 2-苯基甲苯 | CAS号2928-43-0 2-联苯基甲醇 | CAS号84648-93-1 3-(1,1'-biphen-... | CAS号86-73-7 芴 | CAS号19853-10-2 2-([1,1'-联苯]-2-基)乙腈 | CAS号1203-68-5 联苯-2-甲醛 | CAS号191-68-4 二苯并[g,p]稠二萘 | CAS号114049-82-0 N-[(2-phenylphe... | CAS号106912-94-1 2-甲基-[1,1'-联苯]-3-醇

合成工艺路线路线简述

  • 合成目标产物 2-Phenylbenzyl Bromide 主要起始原料 Phenylboronic Acid And 2-Bromobenzyl Bromide
  • (文献来源)合成步骤主要原料 Phenylboronic Acid 和 2-Bromobenzyl Bromide
📜甲基2-联苯羧酸酯置于lithium Aluminium Tetrahydride,氢溴酸体系中,用 乙醚 用作溶剂,化学反应 21.0H,反应生成2-苯基溴化甲基苯
参考文献:芳香族化合物中的碳 13 化学位移张量.3.菲和苯并苯
标题:芳香族化合物中的碳 13 化学位移张量.3.菲和苯并苯
摘要:给出了联苯中的三个碳和菲中的三个不同 α-碳的 13 C 化学位移张量的主要值的测量值.苯联苯中的测量是在室温下在自然丰度样品中进行的,而菲张量是在低温 (~25 K) 下从选择性标记的化合物 (99% 13 C) 中获得的.位移张量的主值使用 Ab Initio Lorg 计算在分子框架中定向
Doi:10.1021/ja00034A011

海关参考信息

专利信息


专利号:WO-2004050654-A1
优先权日:2002-11-29
标 题 :Synthesis of pyrrolidine compound and salt thereof
发明人:KAWANISHI YASUYUKI; UENAKA MASAAKI; IDE YUTAKA; SHINOMOTO SHOJI; OKUNO TAKAYUKI
权利人:SHIONOGI & CO; KAWANISHI YASUYUKI; UENAKA MASAAKI; IDE YUTAKA; SHINOMOTO SHOJI; OKUNO TAKAYUKI
摘要:A p-toluenesulfonate, sulfate, or hydrochloride of the compound represented by the formula (I): (I) a solvate of any of these, or crystals of any of these; and processes for producing these.

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人:SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人:AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人:AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Copper Promoted Synthesis Of Substituted Quinolines From Benzylic Azides And Alkynes
作者:Ching-Zong Luo,Parthasarathy Gandeepan,Yun-Ching Wu,Wei-Chen Chen,Chien-Hong Cheng
摘要:Novel Copper Promoted Synthesis Of Substituted Quinolines From Various Benzylic Azides And Internal Alkynes Has Been Demonstrated. The Reaction Features A Broad Substrate Scope, High Product Yields And Excellent Regioselectivity. In Contrast To The Known Two-Step Process Of Acid Promoted [4 + 2] Cycloaddition Reaction And Oxidation, The Present Methodology Allows The Synthesis Of Quinolines In A Single

合成参考文献


摘要:Evano, G., Science of Synthesis, (2007) 20, 147.
摘要:Braun, M., Science of Synthesis, (2007) 35, 418.
摘要:Lawrence, S. A., Science of Synthesis, (2009) 40, 526.
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