专利号:WO-2004050654-A1 优先权日:2002-11-29 标 题 :Synthesis of pyrrolidine compound and salt thereof 发明人:KAWANISHI YASUYUKI; UENAKA MASAAKI; IDE YUTAKA; SHINOMOTO SHOJI; OKUNO TAKAYUKI 权利人:SHIONOGI & CO; KAWANISHI YASUYUKI; UENAKA MASAAKI; IDE YUTAKA; SHINOMOTO SHOJI; OKUNO TAKAYUKI 摘要:A p-toluenesulfonate, sulfate, or hydrochloride of the compound represented by the formula (I): (I) a solvate of any of these, or crystals of any of these; and processes for producing these.
专利号:US-8193392-B2 优先权日:2005-07-29 标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines 发明人:SCRIBAN CORINA; GLUECK DAVID S 权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE 摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.
专利号:US-6774125-B2 优先权日:1998-06-22 标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H 权利人:ELAN PHARM INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-6509331-B1 优先权日:1998-06-22 标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H 权利人:ELAN PHARM INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-7390801-B2 优先权日:1996-12-23 标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-7999090-B2 优先权日:2000-07-07 标 题:Fungal cell wall synthesis gene 发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.
参考标题:Copper Promoted Synthesis Of Substituted Quinolines From Benzylic Azides And Alkynes 作者:Ching-Zong Luo,Parthasarathy Gandeepan,Yun-Ching Wu,Wei-Chen Chen,Chien-Hong Cheng 摘要:Novel Copper Promoted Synthesis Of Substituted Quinolines From Various Benzylic Azides And Internal Alkynes Has Been Demonstrated. The Reaction Features A Broad Substrate Scope, High Product Yields And Excellent Regioselectivity. In Contrast To The Known Two-Step Process Of Acid Promoted [4 + 2] Cycloaddition Reaction And Oxidation, The Present Methodology Allows The Synthesis Of Quinolines In A Single
合成参考文献
摘要:Evano, G., Science of Synthesis, (2007) 20, 147. 摘要:Braun, M., Science of Synthesis, (2007) 35, 418. 摘要:Lawrence, S. A., Science of Synthesis, (2009) 40, 526.