CAS: 18368-58-6; 5-Methylpyridine-2(1H)-Thione
该化合物是一种环环状有机化合物,其特点是用一个甲基组和硫磷功能组替代的环环,该化合物一般呈现黄色至褐色的浅色外观,其特点是含有含有硫的功能组具有独特的功能组,有助于其反应和各种化学反应中的潜在应用; 甲基组的存在影响其溶性和极性,使其在有机溶剂中溶解,同时在水中溶解较少. 5-M乙-2,1H)-丙烯对硫磷的核循环替代反应可能与硫磷组有关,该组可在某些条件下作为核分裂或分离组发挥作用. 此外,该化合物可能展示生物活动,使其对医药化学和农业应用具有兴趣. 其稳定性,再活性和潜在用途在合成或协调化学中的结合或结合中,是持续研究的领域.
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;; - InChIKey: IYKXPOCKTZADOH-UHFFFAOYSA-N
- InChI=1S/C6H7NS/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8)
- 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0
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27885-58-1 2637-34-5 76041-72-0物理性质
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CAS号3510-66-5 2-溴-5-甲基吡啶 | CAS号1003-68-5 2-羟基-5-甲基吡啶 | CAS号18368-64-4 2-氯-5-甲基吡啶 | CAS号1603-41-4 2-氨基-5-甲基吡啶 | CAS号65938-77-4 5-甲基-2-吡啶磺酰胺 | CAS号733746-65-1 5-甲基吡啶-2-磺酸合成工艺路线路线简述
- 合成目标产物 2-Mercapto-5-Methylpyridine 主要起始原料 2-Bromo-5-Methylpyridine
- (文献来源)合成步骤主要原料 2-Bromo-5-Methylpyridine
📜2-羟基-5-甲基嘧啶置于劳森试剂体系中,用 甲苯 用作溶剂,化学反应 14.0H,反应生成2-疏基-5-甲基吡啶
参考文献:2-吡啶基硫五氟化物的合成与表征
标题:2-吡啶基硫五氟化物的合成与表征
摘要:当前在目标杂环化合物合成过程中制备sf 5取代的杂环的方法要求使用sf 5官能化的芳基或炔试剂或sf 5 Cl作为sf 5 官能团的来源.在这里,我们报告说,用kf / Cl 2 / Mecn系统对2,2'-二吡啶基二硫化物进行过量的氧化氟化会导致形成十三种新的2-吡啶基硫氯四氟化物(2-Sf 4 Cl-吡啶).发现这些分子通过用氟化银(i)处理进一步进行氯-氟交换反应,从而可以立即使用一系列十种新的取代的2-吡啶基五氟化硫(2-Sf 5-吡啶).这是现有杂环硫官能团转化为制备sf 5取代杂环的第一个制备简单且易于扩展的例子.
Doi:10.1002/anie.201409990
海关参考信息
- 2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6310180-B1
优先权日:1993-06-21
标 题 :Method for synthesis of proteins
发明人：TAM JAMES P
权利人:UNIV VANDERBILT
摘要:A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C-α carboxyl groups. The method comprises ligating a first molecule to a second molecule by promoting the orthogonal coupling of the molecules to each other. In an aspect of this method, an acyl-type reaction occurs between the molecules. The method contemplates the joining of molecules of variant size to each other, as well as the coupling of multiple identical molecules. The invention also covers the ligation of unprotected peptide, proteins or nonpeptide segments to prepare therapeutic products and synthetic vaccines with linear, circularized, or branched backbone structures, as well as the site-specific modification of peptides or proteins by lipidation and pegylation.
专利号:WO-2023086801-A1
优先权日:2021-11-09
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
专利号:US-8344118-B2
优先权日:2007-10-31
标 题 :Preparation and isolation of 5′ capped MRNA
发明人：KORE ANILKUMAR; MUTHIAN SHANMUGASUNDARAM; CHARLES IRUDAYA
权利人:APPLIED BIOSYSTEMS LLC; KORE ANILKUMAR; MUTHIAN SHANMUGASUNDARAM; CHARLES IRUDAYA
摘要:The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use in therapeutic applications, diagnosis and prognosis and in the treatment of cancers and HIV.
专利号:WO-2010011325-A2
优先权日:2008-07-23
标题:Synthesis and utilization of small molecules for the treatment of inflammation associated with interleukin-1 signaling
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合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).
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