CAS: 159689-88-0; 1-(Bromomethyl)-3-(Trifluoromethoxy)Benzene

相似化合物

72768-95-7 50824-05-0 3447-53-8

上下游产品

2-(3-(trifluoromethoxy)phenyl)acetic acid H-indole-2-carboxylic acid ethyl ester1-(3-trifluoromethoxy-benzyl)-1H-indole-2-carboxylic acid ethyl ester H-indole-2-carboxylic acid1-(3-trifluoromethoxy-benzyl)-1H-indole-2-carboxylic acid (2R,4R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluorobenzyl)-2,2-dimethyloxazolidin-5-yl]-4-(3-trifluoromethoxy-benzyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester 4-[bis-[[3-(trifluoromethoxy)phenyl]methyl]amino]-1,1,1-trifluoro-2-butanol

3-三氟甲氧基苯乙酸置于silver Triflate-Bis(1,10-Phenanthroline) Complex,1,3-二溴-1,3,5-三嗪-2,4,6-三酮体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 10.0H,以87%的收率获得3-三氟甲氧基溴苄
参考文献:银催化脂肪族羧酸的脱羧溴化反应
标题:银催化脂肪族羧酸的脱羧溴化反应
摘要:描述了银催化的脂肪族羧酸的hunsdiecker溴化.以ag(phen)2 Otf为催化剂,二溴异氰尿酸为溴化剂,各种脂肪族羧酸经过脱羧溴化,在温和条件下提供相应的烷基溴化物.该方法不仅高效通用,而且具有广泛的功能组兼容性.提出了涉及ag(II)中间体的氧化自由基机理.
Doi:10.1021/acs.Orglett.7B00439

专利信息

专利号:WO-2008103866-A1
优先权日:2007-02-22
标题 :Synthesis of indoles
发明人：TALLEY JOHN JEFFREY; RENZE JUERGEN T
权利人:MICROBIA INC; TALLEY JOHN JEFFREY; RENZE JUERGEN T
摘要:Method for preparing indoles, including methods that permit high yield production of particular compounds, are described.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-12410142-B2
优先权日:2017-04-07
标 题:Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof
发明人：DENG XIANMING; LIN SHENGCAI; ZHANG CHENSONG
权利人:XIAMEN VIVOHEALTHS TECH CO LTD
摘要:Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:

专利号:US-4411912-A
优先权日:1978-02-16
标 题 :Insecticidal isovaleric acid esters
发明人：HENRICK CLIVE A; GARCIA BARBARA A
权利人:ZOECON CORP
摘要:Esters and thiolesters of amino acids, intermediates therefor, synthesis thereof, and the use of said esters and thiolesters and compositions for the control of pests.

专利号:US-7825149-B2
优先权日:2006-01-19
标 题 :Substituted imidazoles
发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
权利人:PFIZER LTD
摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.