CAS: 1346242-81-6; N1-(3,5-Dimethoxyphenyl)-N2-Isopropyl-N1-(3-(1-Methyl-1H-Pyrazol-4-yl)Quinoxalin-6-yl)Ethane-1,2-Diamine

上下游产品

2-((3,5-Dimethoxyphenyl)(3-(1-Methyl-1H-Pyrazol-4-yl)Quinoxalin-6-yl)Amino)Ethanol 1346242-78-1
2-((3,5-Dimethoxyphenyl)(3-(1-Methyl-1H-Pyrazol-4-yl)Quinoxalin-6-yl)Amino)Ethyl Methanesulfonate 1346245-10-0
N-(3,5-Dimethoxyphenyl)-N-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethyl]-3 -(1-Methyl-1H-Pyrazol-4-yl)-6-Quinoxalinamine 1346245-08-6
7-溴-2-(1-甲基-1H-吡唑-4-基)喹喔啉 7-Bromo-2-(1-Methyl-1H-Pyrazol-4-yl)Quinoxaline 1083325-87-4

7-溴-2-(1-甲基-1H-吡唑-4-基)喹喔啉置于palladium Diacetate,R-(+)-1,1'-联萘-2,2'-双二苯膦 四丁基溴化铵,Potassium Hydroxide,Sodium T-Butanolate体系中,用 四氢呋喃,1,4-二氧六环,水 用作溶剂,化学反应 2.0H,反应生成厄达替尼
参考文献: Pyrazolyl Quinazoline Kinase Inhibitors[fr] Inhibiteurs De Pyrazolyl-Quinazoline Kinase
标题: Pyrazolyl Quinazoline Kinase Inhibitors[fr] Inhibiteurs De Pyrazolyl-Quinazoline Kinase
摘要:这项发明涉及新的喹喔啉衍生物化合物,包括含有该化合物的药物组合物,制备该化合物的方法以及利用该化合物治疗疾病,例如癌症.

专利信息

专利号:US-12390420-B1
优先权日:2024-10-22
标题 :Compositions for targeted delivery of therapeutic agents and methods for the synthesis and use thereof
发明人：EGUCHI MASAKATSU
权利人:BRYET US INC
摘要:The present disclosure provides compositions and methods for delivering therapeutic agents to particular tissues or cells in a subject. The composition disclosed herein combines unique properties of porous micro- or nano-particles with host-guest chemistry provided by functionalized silicon particle, offering a versatile approach to addressing the challenges associated with delivering therapeutic agents to target tissues or sites within the body. The present disclosure also provides a method for synthesizing a composition capable of delivering therapeutic agents to particular tissues or cells in a subject.

专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

专利号:WO-2025137620-A1
优先权日:2023-12-21
标题:Methods for high quality and high accuracy methylation sequencing
发明人：KENNEDY ANDREW
权利人:GUARDANT HEALTH INC
摘要:Provided herein are methods and compositions for calibrating one or more base calling metrics in a sequencing by synthesis reaction, and for calling at least a portion of nucleobases in a converted region of a DNA molecule using the one or more calibrated base calling metrics. Provided herein are also methods for determining the likelihood that a subject has a disease or condition, such as cancer.

专利号:JP-2024512568-A
优先权日:2021-03-25
标 题:Enamine N-oxide: synthesis and application of hypoxia-responsive prodrugs and contrast agents