CAS: 129791-92-0; Rifalazil

上下游产品

1-isobutylpiperazine 3'-tert-butyldimethylsilyloxybenzoxazinorifamycin 3'-hydroxy-benzoxazinorifamycin 2-aminoresorcinol hydr°Chloride

专利信息

专利号:US-11744867-B2
优先权日:2017-02-14
标 题 :Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease
发明人：NEEDHAM BRITTANY D; MAZMANIAN SARKIS K; SHARON GIL; FUNABASHI MASANORI; FISCHBACH MICHAEL A; HSIAO ELAINE Y; PATTERSON PAUL H
权利人:CALIFORNIA INST OF TECHN; UNIV CALIFORNIA
摘要:Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.

专利号:WO-2018152133-A1
优先权日:2017-02-14
标题 :Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenol sulfate in behavior and disease

专利号:US-11224624-B2
优先权日:2017-02-14
标 题 :Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease

专利号:US-2022096575-A1
优先权日:2017-02-14
标 题 :Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease

专利号:US-2023226197-A1
优先权日:2020-06-18
标 题:Composition and method for new therapeutic agents including guanidinium-presenting dendrimers and branched structures
发明人：WENDER PAUL; CEGELSKI LYNETTE; BRCIC JASNA; CHOSY MADELINE; RAHN HARRISON P; Sun jiuzhi
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The design, synthesis, and biological evaluation of a new family of highly effective conjugate compounds, including dendrimeric moieties and branched structures, are described. Pharmaceutical compositions including the subject dendrimeric conjugates and methods of using the same are also provided. Methods of using the subject dendrimeric conjugates include delivering a cargo moiety conjugated to the dendrimeric moieties and branched structures to a cell under suitable conditions. In certain embodiments, the cell is a bacterial cell population, and the subject compounds reduce the bacterial cell population. In certain embodiments of the methods, the subject compound is capable of eradicating one or more of Gram-positive bacteria, mycobacteria, and Gram-negative bacteria. In certain embodiments of the methods, the subject compound is capable of eradicating bacterial biofilms. Methods of using the subject dendrimeric conjugates include treating a subject for a disease or condition. In certain embodiments, the disease or conditions an infectious disease.