CAS: 128092-72-8; (2-Fluorophenyl)(4-Fluorophenyl)(Phenyl)Methanol

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379-55-5 379-57-7 845790-78-5

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o-fluorobenzophenone 1-Bromo-4-fluorobenzene 2,4'-difluorobenzophenone phenylmagnesium bromide(2-fluorophenyl)-(4-fluorophenyl)phenylchloromethane flutrimazole

📜2,4'-二氟二苯甲酮,Phenylmagnesium Bromide置于盐酸体系中,用 Various Solvent(S) 用作溶剂,化学反应 3.0H,反应生成(2-氟苯基)(4-氟苯基)苯基甲醇
参考文献:Novel Inhibitors Of The Gardos Channel For The Treatment Of Sickle Cell Disease
标题:Novel Inhibitors Of The Gardos Channel For The Treatment Of Sickle Cell Disease
摘要:Sickle Cell Disease (Scd) Is A Hereditary Condition Characterized By Deformation Of Red Blood Cells (Rbcs). This Phenomenon Is Due To The Presence Of Abnormal Hemoglobin That Polymerizes Upon Deoxygenation. This Effect Is Exacerbated When Dehydrated Rbcs Experience A Loss Of Both Water And Potassium Salts. One Critical Pathway For The Regulation Of Potassium Efflux From Rbcs Is The Gardos Channel,A Calcium-Activated Potassium Channel. This Paper Describes The Synthesis And Biological Evaluation Of A Series Of Potent Inhibitors Of The Gardos Channel. The Goal Was To Identify Compounds That Were Potent And Selective Inhibitors Of The Channel But Had Improved Pharmacokinetic Properties Compared To 1,Clotrimazole. Several Triarylamides Such As 10 And 21 Were Potent Inhibitors Of The Gardos Channel (Ic50 Of < 10 Nm) And Active In A Mouse Model Of Scd. Compound 21 (Ica-17043) Was Advanced Into Phase 3 Clinical Trials For Scd.
Doi:10.1021/jm070663S