CAS: 1239-29-8; Furazabol

上下游产品

17β-hydroxy-17α-methyl-(5α)-androstane-2,3-dione dioxime mestanolone 17β-Hydroxy-17α-methyl-androstan-2,3-dion 2-Hydroxylimino-17β-hydroxy-17α-methyl-androstan-3-onc][1,2,5]oxadiazole17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole

📜美雄诺龙置于氢氧化钾,盐酸羟胺,Potassium Tert-Butylate,亚硝酸异戊酯体系中,用 乙二醇,叔丁醇 用作溶剂,化学反应生成夫拉扎勃
参考文献:有关类固醇的研究.Iv.雄甾烷[2,3-C]呋喃丹及其相关化合物的合成.
标题:有关类固醇的研究.Iv.雄甾烷[2,3-C]呋喃丹及其相关化合物的合成.
摘要:合成了与2,3-位融合的呋噁环类固醇.通过2-羟基亚氨基-3-酮(iv)或2,3-二酮(II)从雄甾-3-酮(i)制备的2,3-二羟基亚氨基雄甾烷(III),在碱,琥珀酸酸酐或氯化亚硫酰的作用下,直接环化生成雄甾烷[2,3-C]呋噁烷(xvii).或者,将2,3-二羟基亚氨基化合物(III)用次氯酸钠或四乙酸铅处理,得到相应的呋噁烷n-氧化物(呋氧烷)(xxi),再通过与三乙基磷酸酯加热处理去氧化为呋噁烷(xvii).同样,合成了雄甾-4-烯和雄甾-4,6-二烯[2,3-C]呋噁烷(xvii,Xix).还描述了其衍生物的合成.
Doi:10.1248/cpb.13.1445

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:KR-101513003-B1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications