CAS: 116026-94-9; Tert-Butyl (3-Formylpyridin-2-yl)Carbamate

相似化合物

7521-41-7 32399-08-9 1187932-54-2

上下游产品

CAS号38427-94-0 2-(叔丁氧羰基氨基)吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号2591-86-8 1-甲酰哌啶 | CAS号594-19-4 叔丁基锂 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号504-29-0 2-氨基吡啶 | CAS号54856-61-0 2-氨基-5-氯烟醛 | CAS号521984-94-1 1-methyl-2-phen...

专利信息

专利号:WO-2008022467-A1
优先权日:2006-08-25
标 题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).