CAS: 103548-82-9; (4Ar,5R,10Br)-12-Methyl-2,3,4,4A,5,6-Hexahydro-1H-5,10B-Prop[1]Eno-1,7-Phenanthrolin-8(7H)-One

上下游产品

CAS号89-82-7 蒲勒酮， 胡薄荷酮，长叶薄荷酮 | CAS号1393110-49-0 tert-butyl (R)-... | CAS号1391436-01-3 tert-butyl ((3R... | CAS号612-60-2 7-甲基喹啉 | CAS号3279-76-3 2-羟基-6-甲基吡啶

📜长叶薄荷酮置于sodium Tetrahydroborate,Tris-(Dibenzylideneacetone)Dipalladium(0),四(三苯基膦)钯,氯化亚砜,四丙基高钌酸铵,硼烷四氢呋喃络合物,Palladium 10% On Activated Carbon,氢溴酸,氢气,双氧水,Potassium Carbonate,甲基磺酰氯,N-甲基吗啉氧化物,三乙胺,Sodium Hydroxide,Lithium Diisopropyl Amide,2-二-叔丁膦基-2',4',6'-三异丙基联苯体系中,用 四氢呋喃,乙醇,二氯甲烷,N,N-二甲基乙酰胺,水 用作溶剂,化学反应 40.5H,反应生成石杉碱乙,(4Ar,5S,10Br,12S)-12-Methyl-2,3,4,4A,5,6-Hexahydro-1H-5,10B-Propano-1,7-Phenanthrolin-8(7H)-One
参考文献:石杉碱生物碱石杉碱a,石杉碱b和石杉碱u的不同全合成
标题:石杉碱生物碱石杉碱a,石杉碱b和石杉碱u的不同全合成
摘要:石杉碱甲,石杉碱b和石杉碱u是从中草药石杉石杉(=石柏石藻)中分离出来的同类物,含量极少.石杉碱a的最有效全合成,石杉碱b的第一个不对称全合成和石杉碱u的第一个全合成已分别有效地实现,总收率分别为10%,10%和9%.从(r出发13步)-Pulegone.特色步骤包括钯催化的buchwald-Hartwig偶联和heck环化反应以及ir催化的烯烃异构化反应.这项工作建立了石杉碱b和石杉碱u的绝对构型,并揭示了天然石杉碱a,石杉碱b和石杉碱u具有相同的一组绝对立体化学,从而为石杉碱b和石杉碱u在生物合成中的潜在作用提供了支持.石杉碱甲
Doi:10.1021/jo402419H

专利信息

专利号:US-6271379-B1
优先权日:2000-03-08
标题:Intermediates useful for the synthesis of huperzine A
发明人：TUECKMANTEL WERNER; KOZIKOWSKI ALAN P
权利人:UNIV GEORGETOWN
摘要:Intermediates useful for the synthesis of huperzine A represented by the structures below, n and methods for their synthesis, wherein: n R 1 is lower alkyl, benzyl, or substituted benzyl; n X is a suitable leaving group; n Y is an electron withdrawing group that can subsequently be converted into an amino group; n one broken line is present as a carbon—carbon bond and the other broken line is absent, where the broken line forms an unconjugated carbon—carbon double bond, which double bond may be endocyclic whereby n is 3 or the double bond may be exocyclic whereby n is 2.

专利号:CN-117947461-A
优先权日:2024-01-24
标 题 :Preparation method, structure and application of ultrafine precious metal nanoparticles modified by low-temperature heat treatment synthesis of non-precious metal oxides

专利号:WO-0166524-A2
优先权日:2000-03-08
标题:Intermediates useful for the synthesis of huperzine a

专利号:US-2025236900-A1
优先权日:2022-03-31
标题 :Method for Producing Double-Stranded DNA Molecules Having Reduced Sequence Errors
发明人：SUETSUGU MASAYUKI; KOYAMA TAKUYA; ISHITOBI Hayato
权利人:MODERNA ENZYMATICS CO LTD
摘要:Provided is a method to remove double-stranded DNA with sequence errors, which can occur in various stages of DNA production such as chemical synthesis, hybridization, and amplification, from double-stranded DNA without sequence errors, thereby providing double-stranded DNA with a low proportion of sequence errors. Specifically, this invention is a method for producing double-stranded DNA, which includes: (1) providing a double-stranded DNA mixture containing double-stranded DNA with sequence errors and double-stranded DNA without sequence errors; (2) adding a mismatch repair-related enzyme group to the double-stranded DNA mixture, where the mismatch repair-related enzyme group includes MutS and MutL, or MutS and single-strand specific exonuclease; and (3) subjecting the double-stranded DNA mixture to a double-stranded DNA amplification reaction.