CAS: 88930-14-7; (R)-3-Methyl-2-(Methylamino)Butanoic Acid

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ohmyungsamycin A(3R,6S)-3,6-diisopropyl-4-methyl-2,5-morpholinedione N-Nitroso-N-methyl-valin N-methyl-N-chloroacetyl-DL-valineN-methyl-N-chloroacetyl-DL-valine N-methyl-N-DL-phenylacetyl-valineN-methyl-N-DL-phenylacetyl-valine

📜2-溴代异戊酸置于palladium(II) Oxide Hydrate Sodium Hydroxide,氢气体系中,用 四氢呋喃,乙醇,溶剂黄146 作为反应溶剂,化学反应生成 N-甲基-D-缬氨酸
参考文献:Depsipeptides
标题:Depsipeptides
摘要:
DOI:10.1007/bf00921354

专利信息

专利号:US-10526379-B2
优先权日:2015-06-05
标题:Methods and products for fusion protein synthesis
发明人：HOWARTH MARK
权利人:UNIV OXFORD INNOVATION LTD
摘要:A method of producing a fusion protein is provided. The method includes: a) contacting a first protein with a second protein under conditions that enable the formation of an isopeptide bond between said proteins to form a linked protein; and b) contacting the linked protein from (a) with a third protein under conditions that enable the formation of an isopeptide bond between said third protein and said linked protein to form a fusion protein. Peptide linkers and the use of orthogonal pairs of said linkers in the synthesis of fusion proteins are also provided. Recombinant proteins comprising said linkers, nucleic acid molecules encoding said proteins and linkers, vectors comprising said nucleic acid molecules and host cells comprising said vectors and nucleic acid molecules are also contemplated.

专利号:WO-2008098280-A1
优先权日:2007-02-16
标题:Methods for the synthesis of dicarba bridges in growth hormone peptides
发明人：ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV MONASH; ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
摘要:The invention relates to peptides comprising the carboxy terminal sequence of a growth hormone or an analogue of such a peptide in which the disulfide bridge is replaced by a dicarba bridge. Compositions containing such dicarba bridged peptides and method of treating obesity in an animal such as a human comprising administration of such dicarba bridged peptides are also disclosed.

专利号:US-2023313156-A1
优先权日:2020-08-06
标题 :Chemical synthesis of large and mirror-image proteins and uses thereof
发明人：ZHU TING; Fan Chuyao; DENG QIANG; XU YUAN
权利人:UNIV TSINGHUA
摘要:Provided herein is a general method for producing large (more than 400 aa long) D-amino acids proteins, also referred to as mirror image protein (with respect to their naturally occurring L-amino acids counterparts), including RNA/DNA manipulating enzymes, and uses thereof in a wide range of research, practical data storage and medicinal applications.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-9783490-B2
优先权日:2012-12-18
标 题:Antimicrobial compounds, their synthesis and applications thereof
发明人：HALDAR JAYANTA; GHOSH CHANDRADHISH; MANJUNATH GOUTHAM BELAGULA; AKKAPEDDI PADMA
权利人:THE SEC DEP FOR HEALTH; JAWAHARLAL NEHRU CENTER FOR ADVANCED SCIENT RES; JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENT RES
摘要:The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.

专利号:WO-9411388-A1
优先权日:1992-11-06
标题:Support for the synthesis of modular polymers