CAS: 807-28-3; 1,3-Dimethyl-1,1,3,3-Tetraphenyldisiloxane

相似化合物

1829-40-9 56-33-7 18769-05-6

上下游产品

ethoxy(methyl)(diphenyl)silane (benzyloxy)(methyl)diphenylsilane carbon dioxide 1,2-dimethyl-1,1,2,2-tetraphenyldisilane 1,1,1,3-tetramethyl-3,3-diphenyl-disiloxane diphenylmethylsilanol formaldehyd hydrogen

📜甲基二苯基乙氧基硅烷置于trimethoxonium Tetrafluoroborate,Potassium Carbonate体系中,用 乙腈 作为反应溶剂,化学反应 1.5H,以88%的收率获得产物1,3-二甲基-1,1,3,3-四苯基二硅氧烷
参考文献:使用meerwein试剂从烷氧基硅烷合成对称二硅氧烷的有效方法
标题:使用meerwein试剂从烷氧基硅烷合成对称二硅氧烷的有效方法
摘要:摘要 我们在这里报告了一条新的有效路线,该路线使用meerwein试剂作为介体,碳酸钾作为添加剂,在温和的乙腈反应条件下,从相应的烷氧基硅烷制备对称的二硅氧烷.我们的方法非常简单,经济,高产.我们还提出了与可能的甲硅烷基氧鎓中间体的反应机理. 我们在这里报告了一条新的有效路线,该路线使用meerwein试剂作为介体,碳酸钾作为添加剂,在温和的乙腈反应条件下,从相应的烷氧基硅烷制备对称的二硅氧烷.我们的方法非常简单,经济,高产.我们还提出了与可能的甲硅烷基氧鎓中间体的反应机理.
DOI:10.1055/s-0031-1290668

专利信息

专利号:US-10556913-B2
优先权日:2015-07-21
标 题:Asymmetric process for the preparation of thieno-indoles derivatives
发明人：BERIA ITALO; CARUSO MICHELE; DONATI DANIELE; ORSINI PAOLO
权利人:NERVIANO MEDICAL SCIENCES SRL
摘要:The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (Ia) or (Ib), exploiting an asymmetric synthesis for the preparation of key (8S) or (8R) 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates, and to useful intermediate compounds of such process. n Thieno-indole derivatives are described and claimed in GB2344818, WO2013/149948 and WO2013/149946, which also disclose processes for their preparation. n Thieno-indole enantiopure derivatives can now be advantageously prepared through a new asymmetric synthesis of the key 8-(halomethyl)-7,8-dihydro-6H-thieno[3,2-e]indol intermediates, which, avoiding the chiral resolution step, provides benefits in terms of reducing time and costs of the whole process for their preparation. The synthesis starts from the N-alkylation of 5-amino-4-halo-3-alkyl-1-benzothiophene-7-ol derivatives with enantiopure glycidyl 3-nosylate, followed by intramolecular 6-endo-tet cyclization using alkyl Grignard reagents; Mitsunobu activation of the secondary alcohol promotes internal spirocyclization, affording the 4,4a,5,6-tetrahydro-8H-cyclopropa[c]thieno[3,2-e]indol-8-one derivatives; finally, stereo-electronically controlled regioselective cyclopropane opening yields the key enantiopure 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates; which can be further derivatized following teachings disclosed in WO2013/149948 or WO2013/149946, to prepare the final thieno-indole derivatives of formula (Ia) or (Ib). n Such compounds are disclosed to be alkylating compounds with cytotoxic activity, therefore useful as such in the treatment of a variety of cancers and in cell proliferative disorders, or, conjugated with different types of nucleophiles, in the preparation of Antibody Drug Conjugated derivatives.

专利号:US-10815194-B2
优先权日:2016-11-14
标题 :Process for the preparation of mono-protected α,ω-diamino alkanes
发明人：MENGE WIRO MICHAEL PETRUS BERNARDUS
权利人:BYONDIS BV
摘要:The present invention relates to a process for the synthesis of mono-protected α,ω-diamino alkanes, the use of said process in a process for the synthesis of a linker drug comprising an α,ω-diamino alkane moiety and the use of the process of the present invention in a process for preparing an antibody-drug conjugate comprising an α,ω-diamino alkane moiety.

专利号:WO-9102739-A1
优先权日:1989-08-11
标题:Synthesis of glycosides having predetermined stereochemistry
发明人：DANISHEFSKY SAMUEL J
权利人:UNIV YALE
摘要:Methods of stereoselectively preparing a substituted 1,2-anhydrosugar wherein a substituted glycal is converted into a 1,2-anhydrosugar that is utilized to glycosylate a hydroxyl group containing glycal, are disclosed. Methods of preparing a saccharide multimer wherein a nucleophile is reacted with a substituted 1,2-anhydrosugar having a plurality of non-participating substituents, are disclosed. In addition, methods of preparing stereospecific halo-substituted saccharide multimers by haloglycosylation of a glycosyl donor substituted glycal and a glycosyl acceptor glycal derivative in the absence of water and in the presence of a halonium ion, are disclosed. Methods of preparing stereospecific particle-linked halo-substituted saccharide multimers, by haloglycosylation of a particle-linked nucleophilic hydroxyl group with a substituted glycal and a halonium ion, are also disclosed.

专利号:US-9676698-B2
优先权日:2010-07-20
标 题:Method of producing ingenol-3-angelate
发明人：HOGBERG THOMAS; GRUE-SORENSEN GUNNAR; LIANG XIFU; HORNEMAN ANNE MARIE; PETERSEN ANDERS KLARSKOV
权利人:LEO LABORATORIES LTD
摘要:The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). n n n n n n n n n n Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.

专利号:US-6271370-B1
优先权日:1999-05-11
标 题 :Process for the synthesis of nucleoside analogs
发明人：SCOTT ROBERT W
权利人:PFIZER
摘要:The present invention relates to an improved method for synthesizing nucleosides with a low α:β anomeric ratio. The method comprises coupling a protected furanosyl halide and an appropriately protected heterocycle in the presence of a nucleophilic polar solvent and a strong base.

专利号:US-2018273571-A1
优先权日:2015-01-08
标 题 :Concise synthesis of urea derivatives of amphotericin b