CAS: 723281-55-8; 3-(Morpholine-4-Carbonyl)Phenylboronic Acid

该化合物是一种有机化合物,其特点是存在一种碱性酸功能组和一碱性动物,该化合物通常具有与boronica酸相关的特性,例如能够与二醇形成可逆的共价联系,使其在各种应用中有用,包括有机合成和药用化学.由于在制药中经常发现有光伏,因此,光伏性环有助于其溶解性和潜在的生物活动.该化合物很可能是白色的,在水和乙醇等极溶剂中溶解为白色,在标准实验室条件下可能具有中度稳定性.其再活动可能受到borononica酸组的存在的影响,后者可以参与交叉反应,从而在复杂的有机分子合成中具有价值.此外,该化合物的结构表明与生物目标的潜在相互作用,这可能需要在药物开发过程中作进一步调查.

结构式图片

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    专利信息


    专利号:US-9938258-B2
    优先权日:2012-11-29
    标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
    发明人:BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
    权利人:KARYOPHARM THERAPEUTICS INC
    摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

    专利号:US-9856241-B2
    优先权日:2013-07-03
    标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
    发明人:BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
    权利人:KARYOPHARM THERAPEUTICS INC
    摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

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