专利号:US-2023271983-A1 优先权日:2020-07-29 标题 :Functionalized isonitriles and products, preparation and uses thereof 发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA 权利人:UNIV SANTIAGO COMPOSTELA 摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
1: Ribeiro DB, Santos Silva G, Dos Santos DR, Castro Costa AR, Braga Ribeiro E, Badea M, Nunes GS. Determination of the Antioxidant Activity of Samples of Tea and Commercial Sources of Vitamin C, Using an Enzymatic Biosensor. Antioxidants (Basel). 2021 Feb 22;10(2):324. doi: 10.3390/antiox10020324. 2: Semenova D, Pinto T, Koch M, Gernaey KV, Junicke H. Electrochemical tuning of alcohol oxidase and dehydrogenase catalysis via biosensing towards butanol-1 detection in fermentation media. Biosens Bioelectron. 2020 Dec 15;170:112702. doi: 10.1016/j.bios.2020.112702. Epub 2020 Oct 7. 187(10):550. doi: 10.1007/s00604-020-04477-3. 1572:1-12. doi: 10.1007/978-1-4939-6911-1_1.
合成参考文献
参考文献:10.1016/j.abb.2008.07.006 摘要:Yücel YY, Tacal Ö, Özer I. Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase. Archives of Biochemistry and Biophysics. 2008 Oct;478(2):201–5. doi: 10.1016/j.abb.2008.07.006.