CAS: 67963-68-2; (4-Bromophenoxy)(Tert-Butyl)Dimethylsilane

上下游产品

4-bromo-phenol t-butyldimethylsilyl trichloroacetate tert-butyldimethylsilyl chloride 4-bromophenyl acetate phenyl>-5-phenyl-pentan-1-ol1-4-(tert-butyldimethylsilyl)oxyphenyl-5-phenyl-pentan-1-ol phenyl>-4-phenyl-butan-1-ol1-4-(tert-butyldimethylsilyl)oxyphenyl-4-phenyl-butan-1-ol phenyl>-3-methyl-4-phenylbutan-1-ol1-4-(tert-butyldimethylsilyl)oxyphenyl-3-methyl-4-phenylbutan-1-ol phenyl>-2-hydroxyethyl>piperidine1-benzyl-4-2-4-(tert-butyldimethylsilyl)oxyphenyl-2-hydroxyethylpiperidine

Tert-Butyldimethyl(Phenoxy)Silane置于cerium(Iii) Bromide,双氧水体系中,用 乙腈 作为反应溶剂,以94%的收率获得产物(4-溴苯氧基)叔丁基二甲基硅烷
参考文献:Fenton化学用于achmatowicz重排
标题:Fenton化学用于achmatowicz重排
摘要:Achmatowicz重排(achr)是合成各种杂环结构单元和天然产物的非常重要的转变.在此,已经报道了使用具有环境友好性并且同时具有广泛的底物范围的双功能催化剂(febr 2或cebr 3)对achr的芬顿化学的发现.该方法解决了常规化学(危险)和酶促(有限范围)方法的主要局限性.机理研究表明,反应性溴化物种(rbs)是achr的真正催化剂,Fenton化学[fe / Ce(cat.)+ H2O 2->ho • / Hoo • + H 2O]负责将溴化物氧化为rbs.重要的是,这种在中性条件下由m-Br X-H2O 2反应生成的原位rbs解决了许多卤代过氧化物酶模拟物的长期存在的问题,这些模拟物需要强酸性添加剂/介质来与H2O 2进行溴化物氧化,这创造了机会用于许多其他溴介导的有机反应.
DOI:10.1021/acscatal.1C00219

专利信息

专利号:US-8450365-B2
优先权日:2009-05-12
标 题 :Efficient synthesis of galanthamine
发明人：MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

专利号:US-5075450-A
优先权日:1990-06-28
标 题 :Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes
发明人：RASMUSSON GARY H; TOLMAN RICHARD L; PATEL GOOL F
权利人:MERCK & CO INC
摘要:New intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes, of the formula: ##STR1## wherein R 2 is 2-thiopyridyl, and n R 3 is C 2 -C 4 alkoxycarbonyl, C 1 -C 4 , or trifluoromethylsulfonyloxy. The above compounds are useful intermediates in producing testosterone 5α-reductase inhibitors which are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

专利号:US-7705188-B2
优先权日:2002-04-10
标 题:Structural modification of resveratrol: sodium resverastatin phosphate
发明人：PETTIT GEORGE R; GREALISH MATTHEW P
权利人:UNIV ARIZONA
摘要:Described herein are novel compounds having antineoplastic and antimicrobial activity, obtained via structural modifications of resveratrol and combretastatin A-4, methods for synthesis of these compounds, and their use in pharmaceutical composition and for use in the treatment of mammals having cancer. Examples of the novel compounds are: (Z)- and (E)-3,4′,5-trimethoxystilbene (4a, 4b); (Z)- and (E)-3,5-dimethoxy-4′-hydroxystilbene (14c, 14d); (Z)- and (E)-3-hydroxy-4′,5-dimethoxystilbene (14g, 14h); (Z)- and (E)-3,5-dihydroxy-4′-methoxy-stilbene (14k, 14l); sodium resverastatin dibenzyl phosphate ((Z)-3,5-dimethoxy-4-[O-bis(benzyl)phosphoryl]-stilbene) (14m); and sodium resverastatin phosphate (14n).

专利号:WO-2020226883-A1
优先权日:2019-05-08
标 题 :Synthesis of coelenterazine

专利号:US-2010292475-A1
优先权日:2009-05-12
标 题 :Efficient Synthesis Of Morphine And Codeine

专利号:US-8293927-B2
优先权日:2009-05-12
标 题 :Efficient synthesis of morphine and codeine