CAS: 64248-64-2; 2,5-Difluorobenzonitrile

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CAS号16588-02-6 2-氯-5-硝基苯甲腈 | CAS号256951-83-4 1-B°C-4-CYANO-4... | CAS号256951-82-3 Benzeneacetonit... | CAS号171809-12-4 5-氟-1-甲基-1H-吲唑-3-胺 | CAS号1210023-65-6 5-氟-1-甲基-1H-吲唑 | CAS号119584-77-9 6-氟喹唑啉-2,4-二胺 | CAS号835912-83-9 METHYL 3-AMINO-... | CAS号91407-41-9 2-羟基-5-氟苯腈

2,5-二氯苯甲腈置于fluoride Ion体系中,用 环丁砜 作为反应溶剂,化学反应 6.0H,反应生成 2,5-二氟苯腈
参考文献:一种合成2-氟-5-溴对苯二甲酸的方法
标题:一种合成2-氟-5-溴对苯二甲酸的方法
摘要:本发明公开了一种合成2-氟-5-溴对苯二甲酸的方法,其合成步骤为:先把2,5-二氯苯腈和干燥的氟化钾用环丁砜溶解,加热反应,得到2,5-二氟苯腈(纯度为99%);再一次加入新的环丁砜溶液,通入氯气2小时,得到2-氟-5-氨基苯腈;在经过重氮化处理加入丙烯腈,氢溴酸,加热反应.用稀释用乙酸乙酯进行萃取2-氟-5溴对苯二腈.最后将2-氟-5溴对苯二腈在稀硫酸的水溶液中水解8小时,再一次用乙酸乙酯进行萃取得到15.44G2-氟-5-溴对苯二甲酸,产率为83.99%以上.

专利信息

专利号:US-9790206-B2
优先权日:2013-02-27
标 题:Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof
发明人：EARY C TODD; HACHE BRUNO P; JUENGST DERRICK; SPENCER STACEY RENEE; STENGEL PETER J; WATSON DANIEL JOHN
权利人:ARRAY BIOPHARMA INC
摘要:Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-6235759-B1
优先权日:1998-10-29
标 题 :Dihydropyridinones and pyrrolinones useful as alpha 1A adrenoceptor antagonists
发明人：BARROW JAMES C; NANTERMENT PHILIPPE G; SELNICK HAROLD G
权利人:MERCK & CO INC
摘要:Novel dihydropyridinone and pyrrolinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:EP-0008532-A1
优先权日:1978-08-22
标 题 :Synthesis of amines

专利号:EP-0008532-B1
优先权日:1978-08-22
标 题 :Synthesis of amines

专利号:EP-0040896-A2
优先权日:1978-08-22
标 题 :Synthesis of amides