CAS: 6092-80-4; O-Phenylhydroxylamine Hydrochloride

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N-Phenoxyphthalimide置于一水合肼,盐酸体系中,用 二氯甲烷,1,4-二氧六环 作为反应溶剂,化学反应 2.0H,以99%的收率获得产物o-苯基羟胺 盐酸盐
参考文献:Novel Vascular Leakageage Inhibitor
标题:Novel Vascular Leakageage Inhibitor
摘要:本公开涉及一种新型血管渗漏抑制剂.本发明的新型血管渗漏抑制剂抑制血管内皮细胞凋亡,抑制由vegf诱导的肌动蛋白应激纤维的形成,并增强皮质肌动蛋白环结构,从而抑制血管渗漏.因此,本发明的血管渗漏抑制剂可以预防或治疗由血管渗漏引起的各种疾病.由于本发明的血管渗漏抑制剂是由商业可获得或易于合成的孕酮合成的,因此具有明显优越的商业合成可行性.

专利信息

专利号:US-10717718-B2
优先权日:2015-11-17
标 题:5-azido-5-deoxy-2 :3-isopropylidene-D-arabinose compounds; their method of manufacture and their use for the synthesis of ARA-N3, KDO-N3 and 4EKDO-N3
发明人：VAUZEILLES BORIS; MAS PONS JORDI; BARON AURÈLIE
权利人:CENTRE NAT RECH SCIENT
摘要:Disclosed are new compounds of formulae: n nWherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .

专利号:US-7674881-B2
优先权日:2005-10-07
标题:Convergent synthesis of proteins by kinetically controlled ligation
发明人：KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS
权利人:UNIV CHICAGO
摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.

专利号:US-8691793-B2
优先权日:2003-12-04
标题 :Modified macromolecules and associated methods of synthesis and use
发明人：PRESTWICH GLENN D; SHU XIAO ZHENG; LIU YANCHUN
权利人:PRESTWICH GLENN D; SHU XIAO ZHENG; LIU YANCHUN; UNIV UTAH RES FOUND
摘要:Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking and methods of making and using thereof.

专利号:EP-3377507-A1
优先权日:2015-11-17
标 题 :New 5-azido-5-deoxy-2 :3-isopropylidene-d-arabinose compounds; their method of manufacture and their use for the synthesis of ara-n3, kdo-n3 and 4ekdo-n3

专利号:US-2007082378-A1
优先权日:2005-10-07
标 题 :Convergent synthesis of proteins by kinetically controlled ligation

专利号:WO-2007100358-A2
优先权日:2005-10-07
标题:Convergent synthesis of proteins by kinetically controlled ligation