专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:US-2004266827-A1 优先权日:2003-06-25 标 题 :Convergent asymmetric route to produce a key intermediate towards the synthesis of a garft inhibitor 发明人:NOTZ WOLFGANG REINHARD LUDWIG; MARTINEZ CARLOS ALBERTO 权利人:AGOURON PHARMA 摘要:The invention relates to processes for the preparation of a key intermediate in the synthesis of a GARFT inhibitor of formula (Ia) containing a 4-methyl-substituted thiophene core: n n n wherein said key intermediate has the following formula (I): n n n wherein each of R 1 and R 2 are independently a moiety that together with the attached CO 2 forms a readily hydrolyzable ester group; n from a compound of the formula (VI): n n n wherein R 1 is as described above, Pg 1 is an amino protecting group, and Pg 2 is an ether protecting group; wherein said processes are as described in the specification.
专利号:US-11858953-B2 优先权日:2018-04-04 标 题:Compositions and methods for synthesis of phosphorylated molecules 发明人:CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT 权利人:UNIV CALIFORNIA 摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.
专利号:US-2006183758-A1 优先权日:2005-02-17 标 题:Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans 发明人:BEARD CHARLES D; LEE VING J; WHITTLE C E 权利人:CB RES AND DEV INC 摘要:Methods of synthesis of intermediates that are useful as bioisosteres of the indole, benzofuran and benzothiophene scaffold are disclosed.
专利号:US-4239689-A 优先权日:1978-12-18 标题 :Total synthesis of the utero-evacuant substance d,l-zoapatanol 发明人:KANE VINAYAK V 权利人:ORTHO PHARMA CORP 摘要:A method for the synthesis of racemic 2S*, 3R*-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol is described. The naturally occurring product, 2S, 3R-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol, is one of the active components of the zoapatle plant.
专利号:US-4237053-A 优先权日:1978-12-20 标 题 :Total synthesis of the utero-evacuant substance d,l-zoapatanol 发明人:KANE VINAYAK V 权利人:ORTHO PHARMA CORP 摘要:A method for the synthesis of racemic 2S*,3R*-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol is described. The naturally occurring product, 2S,3R-6E-(2'-hydroxyethylidene)-2-methyl-2-(4',8'-dimethyl-5'-oxo-7'-nonenyl)-oxepan-3-ol, is one of the active components of the zoapatle plant.
摘要:André-Joyaux, E.; Gnägi, L.; Meléndez, C.; Soulard, V.; Renaud, P., Science of Synthesis, (2021) , 461. 摘要:E. M. Arnett and C. Y. Wu. J. Am. Chem Soc. 84, 1684 (1962). 摘要:Das, A.; Sarmah, B. K., Science of Synthesis: Knowledge Updates, (2024) 1, 315. 摘要:Li, X.; Song, Q., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 341. 摘要:Faisca Phillips, A. M.; Guedes da Silva, M. F. C.; Pombeiro, A. J. L., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 557.