CAS: 5558-66-7; 2,2-Diphenylpropanoic Acid

该化合物是一种有机化合物,其独特的结构特征为两个联苯组,附于一种丙基酸酸混合物,典型地是一种白色晶状固体,以水溶性较低而闻名,同时在有机溶剂中更易溶解;它具有箱式酸的典型特性,包括形成氢联结和参加酸基反应的能力;两个苯基组的存在有助于其水恐惧性,并可能影响其回活动及与其他分子的相互作用;2-2-二苯丙基丙基丙基酸经常用于有机合成,并可作为生产药品和其他化学化合物的中间体;此外,其结构特征可能带来具体的生物活动,使其对医药化学具有兴趣;与许多有机酸一样,它应当谨慎处理,遵守适当的安全议定书,以减轻与使用它有关的任何潜在危害.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号5558-67-8 2,2-二苯基丙腈 | CAS号50354-48-8 (Z)-3-bromo-4-e... | CAS号2575-20-4 1,1-diphenyl-1-... | CAS号64-18-6 甲酸 | CAS号599-67-7 1,1-二苯基乙醇 | CAS号86-29-3 二苯乙腈 | CAS号117-34-0 2,2-二苯基乙酸 | CAS号74-88-4 碘甲烷 | CAS号1860-16-8 2-methyl-3,3-di... | CAS号599-67-7 1,1-二苯基乙醇 | CAS号2523-37-7 9-甲基-9H-芴 | CAS号3563-01-7 异戊基丙二酸二乙酯 | CAS号32528-87-3 1,1-diphenyleth... | CAS号74185-82-3 (1-fluoro-1-phe... | CAS号88451-84-7 1-butyl-3-(2,4-... | CAS号4128-37-4 1,3-二异丙基脲 | CAS号1160842-87-4 hexyl-2,2-diphe... | CAS号64589-06-6 Benzamide, N-(1...

合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于chromium(Vi) Oxide体系中,化学反应生成 2,2-二苯基丙酸
    参考文献:Ramart-Lucas,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1912,Vol. 154,P. 1088
    标题:Ramart-Lucas,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1912,Vol. 154,P. 1088

    海关参考信息

    专利信息


    专利号:WO-2015131100-A1
    优先权日:2014-02-28
    标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
    发明人:YU JIN-QUAN
    权利人:SCRIPPS RESEARCH INST
    摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

    专利号:WO-0010565-A1
    优先权日:1998-08-18
    标 题 :Growth hormone secretagogues
    发明人:DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
    权利人:LILLY CO ELI; DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
    摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

    专利号:EP-3515880-B1
    优先权日:2017-03-17
    标题:Methods and compositions for synthesis of encoded libraries
    发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
    权利人:HITGEN INC

    专利号:US-2020149034-A1
    优先权日:2017-03-17
    标题:Methods and Compositions for Synthesis of Encoded Libraries

    专利号:WO-2006079916-A1
    优先权日:2005-01-26
    标 题 :Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation
    发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
    权利人:PHARMACIA & UPJOHN CO LLC; ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:WO-0050406-A1
    优先权日:1999-02-22
    标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAEL
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.
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    合成参考文献


    摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 365.
    摘要:Bellina, F.; Perego, L. A., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 736.
    摘要:Miyabe, H., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 501.
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