CAS: 539-86-6; S-Allyl Prop-2-Ene-1-Sulfinothioate

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蒜氨酸置于immobilized Alliinase体系中,化学反应生成 大蒜素
参考文献:Antimalarial Activity Of Allicin,A Biologically Active Compound From Garlic Cloves
标题:Antimalarial Activity Of Allicin,A Biologically Active Compound From Garlic Cloves
摘要:摘要疟疾发病率不断上升,因此迫切需要确定用于预防和化疗的新药物靶点.潜在的新药靶点包括在寄生虫生命周期中发挥关键作用的质粒蛋白酶.我们之前已经证明,孢子疟原虫的主要表面蛋白--环孢子虫蛋白(csp)是由寄生虫衍生的半胱氨酸蛋白酶进行蛋白水解处理的,这种处理过程与孢子虫侵入宿主细胞的时间相关.e-64是一种半胱氨酸蛋白酶抑制剂,可抑制csp的加工,并防止其在体外和体内侵入宿主细胞.在这里,我们测试了大蒜素(一种存在于大蒜提取物中的半胱氨酸蛋白酶抑制剂)抑制疟疾感染的能力.在低浓度下,大蒜素对孢子虫或哺乳动物细胞均无毒性.在这些浓度下,大蒜素可抑制 Csp 处理,并阻止孢子虫侵入体外宿主细胞.在体内,与对照组相比,注射了大蒜素的小鼠的疟原虫感染率有所下降.如果在向小鼠注射前用大蒜素处理孢子虫,则可完全防止疟疾感染.我们还对大蒜素的红细胞阶段进行了测试,发现口服或静脉注射大蒜素的 4 天方案可显著减少寄生虫血症,并将受感染小鼠的存活期延长 10 天.这些实验共同证明,同一种半胱氨酸蛋白酶抑制剂可以针对脊椎动物宿主两个不同的生命周期阶段.
DOI:10.1128/aac.50.5.1731-1737.2006

专利信息

专利号:US-11897827-B1
优先权日:2022-11-22
标 题 :Carbon isotope exchange mediated by vanadium complexes
发明人：BUKHRYAKOV KONSTANTIN
权利人:BUKHRYAKOV KONSTANTIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal â•?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.

专利号:US-2014357576-A1
优先权日:2013-05-31
标题:Methods for enhancement of muscle protein synthesis
发明人：BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.

专利号:WO-2014009759-A3
优先权日:2012-07-13
标题 :Improvements in or relating to allium extracts
发明人：BENNETT N; RAMSEY EDWARD DALHOUSIE
权利人:LEPTREX LTD
摘要:The present invention relates to improvements in or relating to Allium extracts. In particular, it relates to improvements in or relating to extending the therapeutic half- life or duration of Allium extracts. The invention also relates to the synthesis of certain thiosulfinate compounds, especially to the synthesis of methyl allyl thiosulfinate and allyl methyl thiosulfinate, in particular from either methiin or alliin alone or a mixture of both. The invention further relates to the synthesis of methyl allyl thiosulfinate, allyl methyl thiosulfinate, allicin, and methyl methyl thiosulfinate in a mixture with varying molar or mass ratios depending on the reaction conditions, in particular from either methiin or alliin alone or a mixture of both. A high yielding, optimized synthesis of allicin starts from alliin, whereas methyl methyl thiosulfinate is advantageously obtained from methiin. Also provided is a kit comprising methiin in a first container and/or alliin in a second container and an allinase source, in particular garlic powder in a third container. Finally, the invention provides a method of preparing a mixture of methyl allyl thiosulfinate, allyl methyl thiosulfinate, allyl allyl thiosulfinate (allicin) and methyl methyl thiosulfinate from methiin and pieces of an Allium species.

专利号:WO-2015040533-A1
优先权日:2013-09-19
标题:Methods for enhancing muscle protein synthesis during energy deficit
发明人：BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY
权利人:PREMIER NUTRITION CORP
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.

专利号:US-2014294788-A1
优先权日:2013-03-26
标 题 :Methods for enhancing muscle protein synthesis following concurrent training
发明人：BAILEY DAVID MARK; ZALTAS ERIC SCOTT; MOORE DANIEL RYAN; STELLINGWERFF TRENT
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training. Programs for enhancing muscle adaptation resulting from concurrent training are also provided. The programs include providing a composition comprising from about 15 to about 35 g protein; and providing guidelines for consumption including a recommendation of the amount of the composition to consume immediately following concurrent training.

专利号:US-2014120075-A1
优先权日:2011-05-24
标 题 :Nanozyme Compositions and Methods of Synthesis and Use Thereof
发明人：KABANOV ALEXANDER V; MANICKAM DAVIKA SOUNDARA; BRYNSKIKH ANNA M
权利人:UNIV NEBRASKA
摘要:Nanozymes and methods of use and synthesis thereof are provided.