专利号:WO-2023207921-A1 优先权日:2022-04-25 标题 :Taxamairin analogs and methods of preparation and use thereof 发明人:LEE CHI SING; GE SIYUAN; ZHUANG ANDREW-GO 权利人:UNIV HONG KONG BAPTIST UNIV 摘要:Taxamairin analogs useful in the treatment of cancer, pharmaceutical compositions including the same, methods of use thereof, and methods of preparation are provided. An efficient and scalable semi-synthesis of taxamairin compounds and analogs thereof from readily available commercial starting materials is provided. The synthesis involves low cost and relatively non-toxic reagents and is capable of synthesizing taxamairin A and taxamairin B and analogs thereof on multi-gram scale in yields up 12%and 21%, respectively.
专利号:US-9988492-B2 优先权日:2013-09-30 标题:Methods for post-fabrication functionalization of poly(ester ureas) 发明人:BECKER MATTHEW; LIN FEI 权利人:BECKER MATTHEW; LIN FEI; UNIV AKRON 摘要:Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickableâ€? groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with M w exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1 H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aquous media.
专利号:US-2006223947-A1 优先权日:2005-04-05 标题 :Chemical synthesis of polymeric nanomaterials and carbon nanomaterials 发明人:OLESIK SUSAN V; DING LUNHAN 权利人:UNIV OHIO STATE RES FOUND 摘要:A high yield method for chemically synthesizing low polydispersivity carbon microspheres, nanospheres, nanocrystals, nanotubes, or nanofibers comprising dispersing a self-polymerizing end-capped polyyne in a solvent; heating the dispersed self-polymerizing end-capped tetrayne to form a polymeric material selected from the group consisting of polymer microspheres, polymer nanospheres, polymer nanocrystals, polymer nanotubes, and polymer nanofibers; and pyrolyzing the polymeric material to form a carbon material selected from the group consisting of carbon microspheres, carbon nanospheres, carbon nanocrystals carbon nanotubes, and carbon nanofibers, wherein the polydispersivity is less than 2.
专利号:US-9885035-B2 优先权日:2002-10-30 标 题 :Method for the synthesis of a bifunctional complex 发明人:FRANCH THOMAS; GOULIAEV ALEX HAAHR 权利人:NUEVOLUTION AS 摘要:Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
专利号:WO-2025045973-A1 优先权日:2023-08-31 标题 :Synthesis of lanifibranor intermediate 发明人:BOUBIA BENAÃ?SSA; GONZALEZ JÉRÔME; BELL FRÉDÉRIC 权利人:INVENTIVA 摘要:The present disclosure is directed to a process for preparing a compound of formula (I), which comprises a palladium-free coupling reaction between N-(4-chloro-2-iodo-phenyl)-1,3-benzothiazole-6-sulfonamide and methyl 5-hexynoate in the presence of a copper catalyst.
专利号:WO-2024151591-A1 优先权日:2023-01-10 标 题 :Microwave-assisted synthesis of polyacrylic beads and the use thereof 发明人:TEHRANI ROUZBEH AFSARMANESH; ALIMOHAMMADI FARBOD 权利人:UNIV TEMPLE 摘要:A novel method of synthesizing polyacrylic beads, comprising the steps of suspending a monomer and a cross-linking agent in a solution, heating the solution in a microwave reactor, cooling the solution, and collecting the polyacrylic beads. The polyacrylic beads can be used in to remove solutes from various solutions, including blood, porcine blood, dialysate, serum, contaminated water, wastewater, and combinations thereof.
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