CAS: 50-90-8; 5-Chloro-1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

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951-78-0 119644-22-3 50-91-9

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CAS号6046-63-5 5-氯-3',5'-二-O-乙... | CAS号951-78-0 2’-脱氧尿苷 | CAS号13030-62-1 3',5'-二-O-乙酰基-2... | CAS号54-42-2 碘苷 | CAS号1820-81-1 5-氯尿嘧啶 | CAS号50-89-5 beta-胸苷 | CAS号1820-81-1 5-氯尿嘧啶

📜[(2R,3S,5R)-3-(4-Chlorobenzoyl)Oxy-5-(5-Chloro-2,4-Dioxopyrimidin-1-yl)Oxolan-2-Yl]Methyl 4-Chlorobenzoate置于氨体系中,用 甲醇 作为反应溶剂,化学反应 16.0H,反应生成 5-氯-2-脱氧尿嘧啶核苷
参考文献:5-取代的2'-脱氧尿苷异头体的立体选择性合成
标题:5-取代的2'-脱氧尿苷异头体的立体选择性合成
摘要:研究了5-取代的2,4-双(三甲基甲硅烷氧基)嘧啶与3,5-双(Op-氯苯甲酰基)-2-脱氧-α-D-呋喃核糖基氯的取代反应.在对硝基苯酚的存在下,β端基异构体立体选择性地形成,而有机碱的加入导致α端基异构体的立体选择性形成.反应的立体选择性取决于二甲硅烷基嘧啶的 5 位取代基,添加剂和每种试剂的浓度.5-取代的2'-脱氧-尿苷的α和β异头通过5-取代3',5'-二-O-(对-氯苯甲酰基)-2'-脱氧尿苷的α和β异头脱酰化合成.
DOI:10.1246/bcsj.60.2073

专利信息

专利号:US-2022249426-A1
优先权日:2019-07-24
标题:Inhibitors of the sting pathway for the treatment of hidradenitis suppurativa
发明人：LEVY YVES; HUE SOPHIE; FRANCETTE JEAN-LOUIS; ORVAIN CINDY
权利人:INSERM INSTITUT NAT DE LA SANTE ET DE LA RECHERCH MEDICALE; HOPITAUX PARIS ASSIST PUBLIQUE; UNIV PARIS VAL DE MARNE
摘要:Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease in which the primary abnormality appears to affect the pilosebaceous-apocrine unit. Here, inventors' objective was to characterize the molecular mechanisms involved in the pro-inflammatory phenotype of HS-ORS cells. Transcriptomic analyses of HS-ORS cells demonstrated dysregulation of genes involved in cell proliferation and differentiation, as well as upregulation of the DNA damage response (DDR) and IFN signature. The inventors identified abnormalities in the HF-SC compartment from patients with HS, including high counts of proliferating progenitor cells and loss of quiescent bulge stem cells. Fork progression analysis revealed replicative stress responsible for ATR-CHK1 pathway activation. Accumulation of ssDNA and micronuclei in the cytosol of HS-ORS cells was found to contribute to STING activation via the DNA sensor IF116, inducing IFN synthesis independently of cGAS. STING depletion in ORS cells resulted in modulation of fork progression. These findings support the concept that, in patients with HS, impaired HF-SC homeostasis responsible for increased proliferation induces replicative stress and cytosolic ssDNA accumulation, thereby stimulating IFN synthesis through the STING pathway. Accordingly, inhibiting said pathway would be suitable of the treatment of HS.

专利号:US-6248537-B1
优先权日:1999-05-28
标题:Use of the combing process for the identification of DNA origins of replication
发明人：BENSIMON AARON; HERRICK JOHN; HYRIEN OLIVIER
权利人:PASTEUR INSTITUT; CENTRE NAT RECH SCIENT
摘要:Eukaryotic genomes are duplicated by the activation of multiple bidirectional origins of replication. The replication programs of these cells depend on the temporal and spatial organization of replication origins throughout the genome. To investigate the replication program in a higher eukaryote, we employed a technique called molecular combing. This technique allows for a quantitative analysis of DNA replication on a genome wide basis. As a model system, Xenopus laevis sperm chromatin were differentially labeled at successive time points after the beginning of DNA synthesis. Genomic DNA was then extracted and combed on a glass surface. Direct measurements made on the labeled DNA provided a comprehensive analysis of the spatial and temporal organization of the X. laevis early embryo replication program and revealed that the number of replication origins activated per kilobase increases throughout the period of DNA synthesis. n local freq is {fraction (1/14)} kb global is an increase of 5 fold per 100 kb each time point

专利号:US-2025034520-A1
优先权日:2022-04-08
标 题:Increasing developmental potential of human preimplantation embryos by reducing genetic instability, aneuploidies and chromosomal mosaicism
发明人：EGLI DIETRICH
权利人:UNIV COLUMBIA
摘要:Disclosed herein are agents, compositions and methods for increasing the developmental potential of human preimplantation embryos. n Disclosed herein are methods of reducing or decreasing replication abnormalities and/or aneuploidies in an embryo as well as increasing genome stability and/or developmental potential of an embryo by activating kinases and/or their signaling pathway in an oocyte including but not limited to ATR, WEE1, and CHK1. n Also disclosed herein are methods of reducing or decreasing replication abnormalities and/or aneuploidies in an embryo as well as increasing genome stability and/or developmental potential of an embryo using polynucleotides, polypeptides and/or agents which increase efficiency of the “fork reversion and repairâ€? pathway and/or decrease detrimental outcomes such as fork collapse, translesion synthesis and/or gap formation. n Lastly disclosed herein are methods of reducing or decreasing replication abnormalities and/or aneuploidies in an embryo as well as increasing genome stability and/or developmental potential of an embryo using one or more polynucleotides or polypeptides including but not limited to CHEK1, WEE1, ETAA1, ATRX, BLM, BRCA2, CHD4, DNA2 (DNA2L), EXO1, FANCC, FANCG, FBH1 (FBX018), HLTF (SMARCA3), MCM9, MSH6, POLD3, POLK, RAD51, RAD52, RAD54L, RB1, RECQL, REV3L, RIF1, RNF8, SETD1A, SHPRH, SMARCAL1, TDRD3, TOPBP1, TP53BP1, WRNIP1, XRCC2, WRN, BRCAI, ZRANB3, CDC6, CDT1, POLH, POLI, FANCD2, INO80, FANCB, ASH2L, FAM35A, XRCC3, BRIP1, and NF168.

专利号:US-8614312-B2
优先权日:2008-02-21
标 题 :Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared
发明人：PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE
权利人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II
摘要:The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

专利号:US-4885237-A
优先权日:1985-11-15
标题:Detection of cellular DNA
发明人：EVANS ELIZABETH L; GONCHOROFF NICK J; GREIPP PHILIP R; HOUCK DAVID W; KATZMANN JERRY A; KYLE ROBERT A; LOKEN MICHAEL R
权利人:BECTON DICKINSON CO
摘要:A method is described for the detection of halodeoxyuridines taken up by cells during DNA synthesis by the use of monoclonal antibodies. The described method also allows the simultaneous detection of cell surface receptors.

专利号:EP-1600451-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-l-nucleosides