CAS: 4928-88-5; Methyl 1H-1,2,4-Triazole-3-Carboxylate

上下游产品

CAS号67-56-1 甲醇 | CAS号4928-87-4 1H-1,2,4-三氮唑-3-羧酸 | CAS号26663-10-5 monopotassium s... | CAS号39030-43-8 异利巴韦林(利巴韦林杂质G) | CAS号36791-04-5 利巴韦林 | CAS号24036-63-3 1-苯基-1H-[1,2,4]... | CAS号57031-66-0 1-甲基-1H-1,2,4-三... | CAS号3641-08-5 2H-1,2,4-三氮唑-3-甲酰胺 | CAS号151607-70-4 Methyl 1-trityl... | CAS号21732-98-9 1-H-1,2,4-三氮唑-3-甲酰肼

5-氨基-1H-1,2,4-三氮唑-3-羧酸甲酯置于sodium Hypophosphite,磷酸,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 1.0H,以75%的收率获得产物1,2,4-三氮唑-3-羧酸甲酯
参考文献:一种三氮唑衍生物的制备方法
标题:一种三氮唑衍生物的制备方法
摘要:一种式(1)所示三氮唑衍生物的制备方法,所述方法为:惰性气体保护下,将式(2)所示化合物,酸性物质,还原剂,溶剂混合,在‑40~20oc下加入亚硝酸钠的水溶液,随后在‑20~50oc下反应0.5~5H,之后过滤,滤饼洗涤后干燥,得到式(1)所示三氮唑衍生物;本发明方法避免了分离危险的中间体化合物,同时将重氮化和还原两步反应一锅完成,显著降低了三氮唑衍生物的生产风险和成本;

专利信息

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:CN-104177305-A
优先权日:2014-08-07
标 题 :A new method for the synthesis of triazine rings using mixed solvents

专利号:TW-202045163-A
优先权日:2019-06-04
标 题:Synthesis of 1,2,4-triazole derivatives as anti-inflammation substance and use thereof

专利号:CN-104177305-B
优先权日:2014-08-07
标题 :A new method for the synthesis of triazine rings using mixed solvents

专利号:CN-111471027-B
优先权日:2020-05-21
标题:A kind of synthesis technique and intermediate of ribavirin intermediate

专利号:CN-120230050-A
优先权日:2025-04-28
标 题 :Synthesis method of 1,2, 4-triazole-3-carboxylic acid methyl ester