CAS: 455-00-5; 2,6-Bis(Trifluoromethyl)Pyridine

相似化合物

1620-72-0 368-48-9 1029691-30-2

上下游产品

CAS号626-05-1 2,6-二溴吡啶 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号499-83-2 2,6-吡啶二羧酸 | CAS号6969-51-3 2,6-bis(trichlo... | CAS号110-86-1 吡啶 | CAS号2314-97-8 三氟碘甲烷

吡啶-2,6-二甲酸置于f6Mo体系中,化学反应 45.0H,以84%的收率获得产物2,6-二(三氟甲基)吡啶
参考文献:Shustov,L. D.; Nikolenko,L. N.; Senchenkova,T. M.,Journal Of General Chemistry Of The Ussr,1983,Vol. 53,# 1,P. 85-86
标题:Shustov,L. D.; Nikolenko,L. N.; Senchenkova,T. M.,Journal Of General Chemistry Of The Ussr,1983,Vol. 53,# 1,P. 85-86

专利信息

专利号:US-9428490-B2
优先权日:2011-07-29
标 题 :Nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD
权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD; KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.