CAS: 4152-92-5; (2-(Aminomethyl)Phenyl)Methanol

该化合物是一种双功能有机化合物,其特点是氨基甲基和附于苯环的氢氧化甲基组,这种结构使乙醇成为有机合成的多用途中间体,特别是用于制备药品,农用化学品和特殊化学品.反应性功能组的存在允许进一步衍生,使氨化物,酯类或其他环环化化合物得以形成.在标准条件下和与普通溶剂兼容性下,乙醇的稳定性增强了其在多步骤合成途径中的效用.该化合物通常在惰性条件下处理,以保持其再活性.高纯度可用于满足研究和工业环境中的严格应用要求.

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CAS号7468-67-9 2-氰基苯甲醛 | CAS号6538-31-4 1,5-dihydro-2,4... | CAS号75-05-8 乙腈 | CAS号359010-73-4 5,6-benzo-2-met... | CAS号6587-24-2 邻氰基苯甲酸甲酯 | CAS号7115-95-9 4-oxo-3,4-dihyd... | CAS号91-13-4 α,α'-二溴邻二甲苯 | CAS号50-00-0 甲醛 | CAS号32372-82-0 异吲哚啉盐酸盐 | CAS号496-12-8 异吲哚啉 | CAS号17300-02-6 邻亚二甲苯二胺 | CAS号38379-25-8 (2-(chloromethy... | CAS号39976-24-4 4,5-二氢-2,4-苯并氧氮...

合成工艺路线路线简述

    📜2-氰基苯甲酸甲酯置于lithium Aluminium Tetrahydride体系中,用 乙醚 作为反应溶剂,化学反应生成 2-(氨基甲基)苄醇
    参考文献:Pifferi,G. Et Al.,Gazzetta Chimica Italiana,1966,Vol. 96,P. 1671-1695
    标题:Pifferi,G. Et Al.,Gazzetta Chimica Italiana,1966,Vol. 96,P. 1671-1695

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    专利信息


    专利号:US-9605019-B2
    优先权日:2011-07-19
    标 题:Methods for the synthesis of functionalized nucleic acids
    发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
    权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
    摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

    专利号:US-2018222936-A1
    优先权日:2011-07-19
    标 题:Methods for the synthesis of functionalized nucleic acids

    专利号:US-2017029457-A1
    优先权日:2011-07-19
    标题:Methods for the synthesis of functionalized nucleic acids

    专利号:US-2014194610-A1
    优先权日:2011-07-19
    标 题:Methods for the synthesis of functionalized nucleic acids

    专利号:EP-2734208-B1
    优先权日:2011-07-19
    标题 :Methods for the synthesis of functionalized nucleic acids

    专利号:EP-3248982-A1
    优先权日:2011-07-19
    标 题 :Thiosulfonate reagents for the synthesis of functionalized nucleic acids

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    合成参考文献


    参考文献:10.1023/a:1012380812933
    摘要:Kuznetsov VV, Brusilovskii YE, Mazepa AV, Krasnoshchekaya SP. Reaction of 5,6-Benzo-1,3,2-dioxathiepane 2-Oxide with Acetonitrile. Russian Journal of General Chemistry. 2001 Jan;71(1):150. doi: 10.1023/a:1012380812933.
    参考文献:10.1023/a:1017513522525
    摘要:Kuznetsov VV, Brusilovskii YE, Mazepa AV. Reaction of Seven-membered Cyclic Boric Esters with Acetonitrile. Chemistry of Heterocyclic Compounds. 2001 Jan;37(1):129–30. doi: 10.1023/a:1017513522525.
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