专利号:US-7923459-B2 优先权日:2004-10-13 标题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine 发明人:GAUTHIER DONALD R; DESMOND RICHARD; DEVINE PAUL N 权利人:NSAB AF NEUROSEARCH SWEDEN AB 摘要:The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).
专利号:US-7884125-B2 优先权日:2008-04-30 标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues 发明人:STEVENS CHRISTIAN; HEUGEBAERT THOMAS 权利人:UNIV GENT 摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.
专利号:US-2007238879-A1 优先权日:2004-10-13 标题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
专利号:AU-2005293754-A1 优先权日:2004-10-13 标 题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine
专利号:US-2009275616-A1 优先权日:2008-04-30 标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
专利号:CA-2584831-A1 优先权日:2004-10-13 标题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
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