CAS: 285-69-8; 3,6-Dioxabicyclo[3.1.0]Hexane

相似化合物

286-22-6 86087-24-3 86087-23-2

上下游产品

CAS号1708-29-8 2,5-二氢呋喃 | CAS号453-20-3 3-羟基四氢呋喃 | CAS号4358-64-9 1,4-酐-赤藓糖醇 | CAS号22554-74-1 顺-3,4-二羟基呋喃 | CAS号183184-50-1 (3R,4S)-4-azido...

2,5-二氢呋喃置于间氯过氧苯甲酸体系中,用 二氯甲烷 用作溶剂,化学反应 24.0H,以58%的收率获得3,4-环氧四氢呋喃
参考文献:环氧的有机催化不对称水解
标题:环氧的有机催化不对称水解
摘要:环氧化合物的水解开环是重要的生物合成转化,也已在工业上应用.我们报道了该反应的第一个有机催化变体,它利用了我们最近发现的通过异二聚作用与手性磷酸对羧酸的活化作用.该方法学模拟了酶促机制,其中涉及酶结合的羧酸盐亲核试剂.新设计的磷酸催化剂显示高立体控制中的desymmetrization内消旋环氧化物.该方法在环状,酰基,芳族和脂族底物上显示出广泛的通用性.我们还将我们的方法应用于简单烯烃的第一个高度对映选择性的抗二羟基化反应中.
Doi:10.1002/anie.201400170

专利信息

专利号:US-6472534-B2
优先权日:1999-10-21
标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
发明人：BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K
权利人:AGOURON PHARMA
摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.

专利号:US-2002038033-A1
优先权日:1999-10-21
标题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors

专利号:US-7220870-B2
优先权日:1995-03-14
标 题:Hydrolytic kinetic resolution of cyclic substrates
发明人：JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F
权利人:HARVARD COLLEGE
摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

专利号:US-2003023092-A1
优先权日:1999-10-21
标题 :Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors

专利号:US-2023119463-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

专利号:US-6403799-B1
优先权日:1999-10-21
标题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors