CAS: 256487-77-1; (R)-1-Tert-Butyl 2-Methyl 4-Oxopyrrolidine-1,2-Dicarboxylate

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上下游产品

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(2R,4S)-Methyl 4-Hydroxypyrrolidine-2-Carboxylate置于2,2,6,6-Tetramethyl-Piperidine-N-Oxyl,三氯异氰尿酸,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应生成N-Boc-4-羰基-L-脯氨酸甲酯
参考文献:Part 3: Design And Synthesis Of Proline-Derived α2δ Ligands
标题:Part 3: Design And Synthesis Of Proline-Derived α2δ Ligands
摘要:A Potent Series Of Substituted (2S,4S)-Benzylproline Alpha(2)Delta Ligands Have Been Designed From The Readily Available Starting Material (2S,4R)-Hydroxy-L-Proline. The Ligands Have Improved Pharmacokinetic Profile Over The (4S)-Phenoxyproline Derivatives Described Previously And Have Potential For Development As Oral Agents For The Treatment Of Neuropathic Pain. Compound 16 Has Been Progressed To Clinical Development. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.04.058

专利信息

专利号:US-7691843-B2
优先权日:2002-07-11
标 题 :N-hydroxyamide derivatives possessing antibacterial activity
发明人：RAJU BORE G; O'DOWD HARDWIN; GAO HONGWU; PATEL DINESH V; TRIAS JAOQUIM
权利人:PFIZER
摘要:Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.