CAS: 2480-93-5; Boc-Orn(Z)-Oh

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158599-00-9 3184-13-2 5123-49-9

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号3304-51-6 N'-Cbz-L-鸟氨酸 | CAS号70-26-8 鸟氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号16965-08-5 碳酸叔丁基-2,4,5-三氯苯酯 | CAS号1070-19-5 Carbonazidic ac... | CAS号92235-39-7 (S)-2-哌啶酮-3-氨基甲酸叔丁酯 | CAS号1394857-67-0 tert-butyl (S)-... | CAS号252940-36-6 ((R)-4-tert-But... | CAS号74411-97-5 {3-[(叔丁氧基羰基)氨基]... | CAS号156463-09-1 5-AZIDO-L-NORVALINE | CAS号159877-12-0 (R)-5-Amino-2-(... | CAS号103429-31-8 D-PHE-CYS-TYR-D... | CAS号175133-83-2 benzyl 2-[(3S)-... | CAS号16937-91-0 N'-CBZ-D-鸟氨酸 | CAS号221874-51-7 (R)-叔丁基(2-氧代哌啶-...

📜L-鸟氨酸置于copper(II) Carbonate,Sodium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 15.5H,反应生成N-叔丁氧羰基-N'-苄氧羰基-L-鸟氨酸
参考文献:基于与海洋环肽相关的含噻唑大环内酰胺的新型管状和笼状结构的设计与合成
标题:基于与海洋环肽相关的含噻唑大环内酰胺的新型管状和笼状结构的设计与合成
摘要:在高稀释条件下,L-鸟氨酸和 L-谷氨酸噻唑氨基酸的选择性环三聚化后,从修饰的环肽合成了管状和笼状结构,即 16 和 18.
Doi:10.1039/b101417J

专利信息

专利号:US-2006264608-A1
优先权日:2001-08-03
标题 :Bi-directional synthesis of oligoguanidine transport agents
发明人：WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
权利人:WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
摘要:Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.

专利号:US-7067698-B2
优先权日:2001-08-03
标 题 :Bi-directional synthesis of oligoguanidine transport agents
发明人：WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.

专利号:EP-1586566-B9
优先权日:2004-03-29
标 题:P-toluenosulfonate salt of N-Methyl-N-(3,5-dimathoxy-2,4,6-triazinyl-1-)-morpholine and related compounds for use as condensing reagent in peptide synthesis
发明人：KAMINSKI ZBIGNIEW; KOLESINSKA BEATA; KOLESINSKA JUSTYNA; JASTRZABEK KONRAD
权利人:POLITECHNIKA LODZKA; KAMINSKI ZBIGNIEW; KOLESINSKA BEATA
摘要:The invention refers to new quarternary N-(3,5-disubstituted-1,3,5-triazinyl-1)-ammonium salts of sulfonic acids, with formula 1, where R1 and R2 denote in total or independently a halogen atom, an alkyl group, a substituted alkyl group, an alkoxy group, a substituted alkoxy group, a cycloalcoxy group, a substituted cycloalkoxy group, an aryl group, a substituted aryl group, an aryloxy group, a substituted aryloxy group, a heterocyclic group or a substituted heterocyclic group, preferably the methoxy group, where R3, R4, R5 denote independently each other an alkyl group, a substituted alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an aryl group, a substituted aryl group, a heterocyclic or a substituted heterocyclic group, or form a heterocyclic ring with nitrogen atom, whereas O-SO2R6 denotes a sulfate anion, hydrosulfonate anion, arylsulfonate anion, preferable benzenosulfonate anion, p-toluenosulfonate anion, p-bromobenzenosulfonate anion, p-chlorobenzenosulfonate anion, alkylosulfonate anion, preferable methanosulfonate and trifluoromethanesulfonate anions or amidosulfonate anion. The new compounds are designed for application as condensing reagents in syntheses of amides, esters, carboxylic acid hydroxides, and particularly in synthesis of peptides and their esters.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:CA-2455951-A1
优先权日:2001-08-03
标 题 :Bi-directional synthesis of oligoguanidine transport agents