专利号:US-2025289845-A1 优先权日:2023-02-21 标题 :Substrate for solid-phase organic synthesis and solid-phase organic synthesis method using the same 发明人:KANG SUNG KOO 权利人:KANG SUNG KOO 摘要:The present invention relates to a substrate for solid-phase organic synthesis and a solid-phase organic synthesis method using the same. More specifically, the present invention relates to a substrate having a larger reactive surface area compared to conventional solid-phase resins, thereby improving the efficiency of solid-phase organic synthesis reactions, and also being applicable to continuous organic synthesis via a roll-to-roll process.
专利号:US-2010029911-A1 优先权日:2004-11-24 标题 :Method For Solid-Phase Peptide Synthesis And Purification 发明人:FRANK HANS-GEORG; CASARETTO MONIKA; KNORR KARSTEN 权利人:APLAGEN GMBH 摘要:Use of an activated solid phase and a peptide-conjugated anchoring part for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase.
专利号:US-2003228619-A1 优先权日:2002-06-10 标题:Peptide nucleic acids as tags in encoded libraries 发明人:NEEDELS MICHAEL C 权利人:XENOPORT INC 摘要:Methods of screening a library of compounds are disclosed herein. The methods include providing a library of differing complexes. Each complex includes a compound and a peptide nucleic acid tag encoding one or more synthesis steps by which the compound was made, the compounds and the tags encoding them differing between the different complexes. Usually, the complex is cleavably bound to a support. One preferred support is polyethylene glycol (PEG), and optionally the PEG support is attached to a dendrimer. The library of differing complexes is then contacted with a molecular target (e.g., a receptor or enzyme). A complex(es) that bind to the target is isolated. The isolated complex(es) is contacted with a nucleic acid that hybridizes to the tag of the complex. The tag is decoded from the identity of the nucleic acid that hybridizes to the tag, thereby identifying the compound which binds to the target.