CAS: 247021-90-5; 3-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)(Methoxy)Amino)Propanoic Acid

该化合物是一种多用途化学试剂,在有机合成中广泛使用,特别是用于控制氨化物和氯酮的形成,其主要优势在于它能够稳定中间体,防止反应过度和促成选择性转换. Weinreb 链接器与有机金属试剂发生反应,形成稳定的复合体,然后可以进行水解,产生氯酮或进一步衍生,以高效地粘合.这种特性使其在多步骤合成中具有价值,特别是在制药和精细化学应用中.它与广泛的功能组的兼容性进一步增强了其在复杂分子构造中的效用.该链接的可靠性和可预测性有助于其在合成化学中广泛采用.

结构式图片

相似化合物

172965-84-3 35737-10-1 172299-81-9

上下游产品

氯甲酸-9-芴基甲酯 (Fluorenylmethoxy)Carbonyl Chloride 28920-43-6

合成工艺路线路线简述

    Tert-Butyl 3-[9H-Fluoren-9-Ylmethoxycarbonyl(Methoxy)Amino]Propanoate置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应生成魏因勒卜链接剂
    参考文献:天冬氨酰肽醛的固相合成
    标题:天冬氨酰肽醛的固相合成
    摘要:已经开发了一种高效固相合成天冬氨醛醛肽的方法.它使用低成本的合成方法来制备fmoc保护的weinreb酰胺连接基.该程序涵盖了几种四肽天冬氨酰醛以及生物素化的四肽天冬氨酰醛.
    Doi:10.1016/s0040-4039(00)01615-4

    海关参考信息

    专利信息


    专利号:US-2025289845-A1
    优先权日:2023-02-21
    标题 :Substrate for solid-phase organic synthesis and solid-phase organic synthesis method using the same
    发明人:KANG SUNG KOO
    权利人:KANG SUNG KOO
    摘要:The present invention relates to a substrate for solid-phase organic synthesis and a solid-phase organic synthesis method using the same. More specifically, the present invention relates to a substrate having a larger reactive surface area compared to conventional solid-phase resins, thereby improving the efficiency of solid-phase organic synthesis reactions, and also being applicable to continuous organic synthesis via a roll-to-roll process.

    专利号:US-2010029911-A1
    优先权日:2004-11-24
    标题 :Method For Solid-Phase Peptide Synthesis And Purification
    发明人:FRANK HANS-GEORG; CASARETTO MONIKA; KNORR KARSTEN
    权利人:APLAGEN GMBH
    摘要:Use of an activated solid phase and a peptide-conjugated anchoring part for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase.

    专利号:US-2003228619-A1
    优先权日:2002-06-10
    标题:Peptide nucleic acids as tags in encoded libraries
    发明人:NEEDELS MICHAEL C
    权利人:XENOPORT INC
    摘要:Methods of screening a library of compounds are disclosed herein. The methods include providing a library of differing complexes. Each complex includes a compound and a peptide nucleic acid tag encoding one or more synthesis steps by which the compound was made, the compounds and the tags encoding them differing between the different complexes. Usually, the complex is cleavably bound to a support. One preferred support is polyethylene glycol (PEG), and optionally the PEG support is attached to a dendrimer. The library of differing complexes is then contacted with a molecular target (e.g., a receptor or enzyme). A complex(es) that bind to the target is isolated. The isolated complex(es) is contacted with a nucleic acid that hybridizes to the tag of the complex. The tag is decoded from the identity of the nucleic acid that hybridizes to the tag, thereby identifying the compound which binds to the target.
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    合成参考文献


    摘要:Lubell, W. D.; Blankenship, J. W.; Fridkin, G.; Kaul, R., Science of Synthesis, (2005) 21, 784.
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