CAS: 2365-85-7; 3-Amino-4-Fluorobenzoic Acid

上下游产品

CAS号453-71-4 4-氟-3-硝基苯甲酸 | CAS号369-26-6 3-氨基-4-氟苯甲酸甲酯 | CAS号227609-87-2 (4-氟-3-碘苯基)甲醇 | CAS号227609-86-1 (3-氨基-4-氟苯基)甲醇 | CAS号227609-88-3 4-氟-3-碘苯甲醛 | CAS号503859-27-6 3-氨基-4-(环己基氨基)苯甲酸甲酯 | CAS号55296-17-8 3-氨基-4-苯基氨基苯甲酸 | CAS号639858-51-8 3-氨基-N-环丙基-4-氟苯甲酰胺

4-氟-3-硝基苯甲酸置于铁粉,溶剂黄146体系中,用 甲醇 用作溶剂,化学反应 4.0H,以91%的收率获得3-氨基-4-氟苯甲酸
参考文献:C-h...x(x = F,Cl)分子内氢键诱导的芳族三唑折叠剂
标题:C-h...x(x = F,Cl)分子内氢键诱导的芳族三唑折叠剂
摘要:设计合成了基于4-氟苯甲酸异丁酯和4-氯苯甲酸异丁酯的芳基三唑低聚物.晶体结构和1 H-1 H Noesy实验表明,低聚物具有稳定的螺旋构象,这是由三唑质子和卤素原子之间的c 5-h..x-c(x = F,Cl)分子内氢键诱导的.折叠构象的稳定性通过dft计算得到了证实,Dft计算表明,每一个c 5-h...f-c平面相互作用都会使能量平均降低〜3 Kcal Mol-1,而当降低时,能量降低〜1 Kcal Mol-1. C 5形成-h...cl-c桥.氢键网络在竞争性氢键介质(如dmso)中被破坏,生成未折叠的低聚物.
Doi:10.1021/jo500582C

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

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