专利号:US-6166031-A 优先权日:1987-10-19 标 题:Substituted tetralins, chromans and related compounds in the treatment of asthma 发明人:EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S 权利人:PFIZER 摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions comprising said compounds; a method of treatment with said compounds; and intermediates useful in the synthesis of said compounds.
专利号:US-5504104-A 优先权日:1993-11-19 标 题:Tricyclic pyrone derivatives as protease inhibitors and antiviral agents 发明人:ELLSWORTH EDMUND L; TAIT BRADLEY D 权利人:WARNER LAMBERT CO 摘要:The present invention relates to novel substituted tricyclic pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The tricyclic pyrone derivatives are useful in the development of therapies for the treatment of vital infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized tricyclic pyrones and of related structures.
专利号:US-5998451-A 优先权日:1987-10-19 标 题 :Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases 发明人:EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S 权利人:PFIZER 摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.
专利号:CN-109265431-A 优先权日:2018-10-09 标 题 :Synthesis process of 3-acetyl-10,11-dihydro-5H-dibenzo[C,G]chromene-8(9H)-one
专利号:CN-109265431-B 优先权日:2018-10-09 标 题 :Synthesis process of 3-acetyl-10, 11-dihydro-5H-dibenzo [ C, G ] chromen-8 (9H) -one
参考文献:10.1371/journal.pone.0021922 摘要:Hunt PR, Son TG, Wilson MA, Yu Q, Wood WH, Zhang Y, Becker KG, Greig NH, Mattson MP, Camandola S, Wolkow CA. Extension of Lifespan in C. elegans by Naphthoquinones That Act through Stress Hormesis Mechanisms. PLoS ONE. 2011 Jul 13;6(7):e21922. doi: 10.1371/journal.pone.0021922.