CAS: 214279-40-0; 2-Iodo-4-Methoxy-1-Nitrobenzene

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CAS号16133-49-6 5-甲氧基-2-硝基苯胺 | CAS号50590-07-3 3-碘-4-硝基苯酚 | CAS号74-88-4 碘甲烷 | CAS号766-85-8 3-碘苯甲醚 | CAS号626-02-8 3-碘苯酚 | CAS号105469-13-4 2-碘-4-甲氧基苯甲醛 | CAS号77-78-1 硫酸二甲酯 | CAS号10205-69-3 6-methoxy-2-phe... | CAS号101078-51-7 6-甲氧基-2-(对甲苯基)苯... | CAS号191348-14-8 2-碘-4-甲氧基苯基胺 | CAS号861025-09-4 3-(5-methoxy-2-... | CAS号923293-14-5 4-methoxy-2-pyr...

📜5-甲氧基-2-硝基苯甲酸置于copper(L) Iodide,氧气体系中,用 二甲基亚砜 用作溶剂,160.0 °C,101.33 Kpa 条件下,反应 30.0H,以49%的收率获得3-碘-4-硝基茴香醚
参考文献:在缺氧条件下,通过铜介体以及富电子的pd催化剂对缺电子的芳基羧酸进行脱羧卤化和氰化
标题:在缺氧条件下,通过铜介体以及富电子的pd催化剂对缺电子的芳基羧酸进行脱羧卤化和氰化
摘要:建立了一种简单的策略,在需氧条件下,通过使用cu(i)作为促进剂和富电子的pd(II)作为催化剂,对缺电子的苯甲酸进行脱羧功能化的简单策略,从而导致芳基卤化物(-I)的顺利合成,Br和cl),通过使用容易获得的卤素源cux(x = I,Br,Cl)对苯甲酸进行脱羧功能化,以及使用无毒且低成本的k 4 Fe通过芳基羧酸的脱羧氰化反应轻松制备苄腈(cn)6第一次在氧气气氛下.
Doi:10.1021/acs.Joc.5B02873

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:EP-2173721-B1
优先权日:2007-06-26
标 题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CN-101687865-A
优先权日:2007-06-26
标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles