CAS: 2086-26-2; O-(4-Nitrobenzyl)Hydroxylamine Hydrochloride

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CAS号30777-85-6 2-((4-硝基苄基)氧基)异... | CAS号1944-96-3 O-(4-硝基苄基)羟胺 | CAS号100-11-8 4-硝基溴化苄 | CAS号31150-87-5 (4-nitrophenyl)...

N-[(4-硝基苯基)甲氧基]苯甲酰胺置于盐酸体系中,用 乙醇 用作溶剂,化学反应 0.25H,反应生成4-硝基苄基羟胺盐酸盐
参考文献:新的钙拮抗剂:3-[o-(苄基取代的)-肟基醚]-六氢a庚因-2,3-二酮的合成,X射线分析和平滑肌松弛作用.
标题:新的钙拮抗剂:3-[o-(苄基取代的)-肟基醚]-六氢a庚因-2,3-二酮的合成,X射线分析和平滑肌松弛作用.
摘要:由相应的六氢a庚因-2,3-二酮制备了一系列新的z和e 3-[o-(苄基取代的-肟基醚)-六氢hydro庚因-2,3-二酮,并作为平滑肌松弛剂进行了测试.E和z结构通过NMR分析确定,并通过使用同步加速器辐射的x射线衍射确定16(e和z).硝基苄基衍生物16是体外最有效的用乙酰胆碱预收缩的大鼠气管松弛剂.E异构体16B比z异构体16A更有效.E异构体16B比氨茶碱更有效地松弛大鼠气管和人支气管.该衍生物主要通过抑制细胞外钙的流入而起作用,因为它在去极化介质中有效和剂量依赖性地抑制大鼠气管收缩至高浓度的kci和cacl2.它似乎通过诱导cgmp和camp合成而作用较弱.而且,其松弛活性与磷酸二酯酶的抑制,钾通道的开放或前列腺素合成的诱导无关.因此,16B似乎主要作为有效的钙拮抗剂起作用.
Doi:10.1016/s0968-0896(99)00090-5

专利信息

专利号:US-7674881-B2
优先权日:2005-10-07
标题:Convergent synthesis of proteins by kinetically controlled ligation
发明人：KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS
权利人:UNIV CHICAGO
摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.

专利号:US-2007082378-A1
优先权日:2005-10-07
标 题 :Convergent synthesis of proteins by kinetically controlled ligation

专利号:US-8758741-B2
优先权日:2005-03-30
标 题 :Gene expression cassette and a transformant, and a method for manufacturing 2-deoxy-scyllo-inosose and a method for purifying 2-deoxy-scyllo-inosose using said transformant
发明人：TAKAGI MASAMICHI; KOGURE TAKAHISA; WAKISAKA NAOKI; TAKAKU HIROAKI; AJISAKA KATSUMI; MIYAZAKI TATSUO; HIRAYAMA MASAO
权利人:TAKAGI MASAMICHI; KOGURE TAKAHISA; WAKISAKA NAOKI; TAKAKU HIROAKI; AJISAKA KATSUMI; MIYAZAKI TATSUO; HIRAYAMA MASAO; MITSUI CHEMICALS INC; NIIGATA BIO RES PARK INC
摘要:A transformant is prepared to insert at least a gene expression cassette comprising a gene involved in the synthesis of 2-deoxy-scyllo-inosose into E. coli as host cells. A 2-deoxy-scyllo-inosose is synthesized from D-glucose, oligosaccharide, polysaccharide, starch and rice bran, using the transformant. A culture solution containing the 2-deoxy-scyllo-inosose is treated with a mixed bed or double bed type column comprising a hydrogen form of strong acidic cation exchange resin and an organic ion form of basic anion exchange resin. The 2-deoxy-scyllo-inosose as purified is reacted with trimethoxymethane to convert into 2-deoxy-scyllo-inosose dimethylketal, and the dimethylketal is crystallized and purified. Then, DOI is highly purified through hydrolyzing the dimethylketal in the presence of acid.

专利号:US-5658942-A
优先权日:1987-10-27
标题:Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition
发明人：KURABAYASHI MASAAKI; KOGEN HIROSHI; KADOKAWA HIROSHI; KURIHARA HIDESHI; HASEGAWA KAZUO; KURODA MASAO
权利人:SANKYO CO
摘要:Compounds of formula (I): (I) in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y represents hydrogen, or an aryl, cycloalkyl or heterocyclic group; have valuable antihypercholesteremic activities and may be used in the treatment of disorders arising from a blood cholesterol imbalance in humans and other animals.