CAS: 2050-07-9; 4-Methyl-1-Phenylpentan-1-One

上下游产品

苯丙酮 1-Phenyl-Propan-1-One 93-55-0
3-氯代苯丙酮 3-Chloropropiophenone 936-59-4
苯乙酮 Acetophenone 98-86-2

📜Magnesium,2-Methylbutane,Bromide置于oxidizing Agent体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成4-甲基-1-苯基戊烷-1-酮
参考文献:远程未激活的c(sp3)-H键的区域选择性乙烯基化:访问复杂的氟烷基化烯烃.
标题:远程未激活的c(sp3)-H键的区域选择性乙烯基化:访问复杂的氟烷基化烯烃.
摘要:通过直接活化未反应的ch键将特定的官能团区域选择性地引入脂族位置具有很大的合成价值.尽管通过氢原子转移过程在自由基介导的c(sp 3)-H键的官能化方面取得了进展,但远端c(sp 3)-H键的位点选择性乙烯基化仍处于探索中.本文报道的是一种新的协议,用于未激活的c(sp 3)-H键的区域选择性乙烯基化.远程c(sp 3)-H活化是由以c为中心的自由基而不是常用的n和o自由基促进的.该反应具有很高的产物多样性和合成效率,提供了大量合成有价值的e 带有三/二/单氟甲基和全氟烷基的烯烃
Doi:10.1002/anie.201812927

专利信息

专利号:US-6465693-B2
优先权日:1998-02-26
标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
发明人：BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

专利号:US-5936128-A
优先权日:1993-11-19
标题:5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
发明人：ELLSWORTH EDMUND LEE; LUNNEY ELIZABETH; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.

专利号:WO-2007044270-A1
优先权日:2005-10-06
标 题:Process for producing high purity ketones by friedel-crafts acylation at low temperature
发明人：MANIMARAN THANIKAVELU; HARKINS ALVIN E
权利人:ALBEMARLE CORP; MANIMARAN THANIKAVELU; HARKINS ALVIN E
摘要:The present invention relates to improved conditions for the Friedel-Crafts acylation of alkylbenzenes and to application of these improved conditions to the synthesis of para-isobutyl acetophenone and ibuprofen. The reaction conditions include operating the reaction at a temperature below 0°C and typically below -10° C.

专利号:US-5840751-A
优先权日:1993-11-19
标题 :5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
发明人：ELLSWORTH EDMUND LEE; LUNNEY ELIZABETH; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.

专利号:US-5723708-A
优先权日:1994-09-29
标 题 :Method for producing cyclopentadienes
发明人：MATSUMURA YASUO; SUYAMA KAZUHARU; INOMATA YOSHIHISA
权利人:NIPPON PETROCHEMICALS CO LTD
摘要:A method for producing cyclopentadienes which comprises the step of cyclodehydration of an unsaturated carbonyl compound having a specific chemical structure in a vapor phase in the presence of a specific solid acid catalyst. The cyclopentadienes of the invention can be produced in a high yield from inexpensive starting materials through a simplified reaction process and are useful as intermediate compounds for organic synthesis.

专利号:CN-102516062-A
优先权日:2011-12-02
标题:A kind of Friedel-Crafts reaction solution hydrolysis external circulation heat exchange process and device for ibuprofen synthesis