CAS: 1885-29-6; 2-Aminobenzonitrile

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2-Methyl-2-Ethylindoline置于chromium(Vi) Oxide,氯化亚砜,盐酸羟胺,溶剂黄146,Potassium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,1,2-二氯乙烷 用作溶剂,化学反应 47.0H,反应生成2-氨基苯甲腈
参考文献:2-位-2-乙基-2-甲基-2,3-二氢-1 H-吲哚的转化
标题:2-位-2-乙基-2-甲基-2,3-二氢-1 H-吲哚的转化
摘要:用氯铬酸吡啶鎓,Cro 3 .2 Py或cro 3氧化n-乙酰基-2-乙基-2-甲基-2,3-二氢-1 H-吲哚,得到n-乙酰基-2-乙基-2-甲基将-2,3-二氢-1 H-吲哚-3-酮水解成2-乙基-2-甲基-2,3-二氢-1 H-吲哚-3-酮.后者在乙醇中用四氢硼酸钠还原为3-羟基衍生物,并通过在甲醇中用盐酸羟胺处理而转化为相应的肟.研究了2-乙基-2-甲基-2,3-二氢-1 H-吲哚-3-一的baeyer-Villiger氧化及其肟的贝克曼重排.
Doi:10.1134/s1070428020010133

专利信息

专利号:US-11447454-B2
优先权日:2015-08-07
标题:Synthesis of benzodiazepine derivatives
发明人：BOYCE MALCOLM JAMES; THOMSEN LIV; GILBERT DONALD ALAN; WOOD DAVID
权利人:TRIO MEDICINES LTD
摘要:The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:

专利号:US-2015336900-A1
优先权日:2012-10-29
标题 :Process for the Synthesis of Etravirine and Its Intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The invention discloses the synthesis of Etravirine via intermediate 4-((4-amino-5-bromo-6-chloropyrimidin-2-yl) amino)benzonitrile and process for the preparation of Etravirine of the formula-I.

专利号:US-9278929-B1
优先权日:2013-02-21
标 题 :Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics
发明人：WALZ ANDREW J; HSU FU-LIAN
权利人:U S ARMY EDGEWOOD CHEMICAL AND BIOLOG COMMAND; US ARMY
摘要:An improved process or method of synthesis of carfentanil and other potent opioid analgesics of the N-alkyl 4-substituted 4-piperdinylamide class which can be used as morphine substitutes.

专利号:US-5527824-A
优先权日:1985-07-22
标题 :Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis
发明人：SCHERRER ROBERT A
权利人:RIKER LABORATORIES INC
摘要:Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed.

专利号:US-7256197-B2
优先权日:2001-10-12
标 题 :Methods for synthesis of diarylmethanes
发明人：ROSOWSKY ANDRE; CHEN HAN
权利人:DANA FARBER CANCER INST INC
摘要:The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.

专利号:US-9969686-B2
优先权日:2014-08-05
标 题 :Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; LI XIAOXUN; SHU DONGXU; WINSTON-MCPHERSON GABRIELLE N
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.