CAS: 18791-75-8; 4-Bromo-2-Thiophenecarboxaldehyde

上下游产品

CAS号872-31-1 3-溴噻吩 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号98-03-3 2-噻吩甲醛 | CAS号38071-22-6 4,5-二溴噻吩-2-甲醛 | CAS号3140-92-9 2,4-二溴噻吩 | CAS号3779-27-9 2,2'-联噻吩-5-甲醛 | CAS号41498-07-1 4-溴-5-硝基-2-噻吩甲醛 | CAS号144558-44-1 3-(4-溴-2-噻吩)丙烯酸 | CAS号142057-51-0 4-bromo-2-ethen... | CAS号222554-16-7 2-Thiophenecarb... | CAS号937-14-4 间氯过氧苯甲酸 | CAS号224958-14-9 4-bromo-2-(diet... | CAS号232280-88-5 5-(氨基甲基)噻吩-3-甲腈 | CAS号79387-71-6 5-溴-2-噻吩甲醇 | CAS号79757-77-0 (4-溴-2-噻吩基)甲醇

2-(4-Bromothiophen-2-yl)-1,3-Oxathiolane置于eosin Y Disodium Salt体系中,用 乙腈 用作溶剂,化学反应 3.0H,以83%的收率获得4-溴-2-噻吩甲醛
参考文献:Visible Light Photoredox Catalyzed Deprotection Of 1,3-Oxathiolanes
标题:Visible Light Photoredox Catalyzed Deprotection Of 1,3-Oxathiolanes
摘要:公开了一种温和且有效的可见光光氧化还原催化空气氧化的1,3-氧硫杂环戊烷去保护方法,使用曙红y作为光催化剂.
Doi:10.1039/c9Ob02517K

专利信息

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

专利号:US-7635781-B2
优先权日:2001-05-15
标 题:Synthesis of cyclopentadiene derivatives
发明人：NIFANT EV ILYA; KASHULIN IGOR; IVCHENKO PAVEL; KLUSENER PETER; KORNDORFFER FRANS; DE KLOE KEES; RIJSEMUS JOS
权利人:BASELL POLYOLEFINE GMBH
摘要:A compound of formula (X): n n n n n n n n n n n n wherein n R 1 , R 2 , equal to or different from each other are hydrogen or a linear or branched saturated or unsaturated C 1 -C 20 -alkyl, C 3 -C 20 -cycloalkyl, C 6 -C 20 -aryl, C 7 -C 20 -alkylaryl or C 7 -C 20 -arylalkyl radical, optionally containing heteroatoms belonging to groups 13-17 of the Periodic Table of the Elements; or they can form a C 4 -C 7 ring optionally containing O, S, N, P or Si atoms that can bear substituents; n R 3 is hydrogen or a linear or branched saturated or unsaturated C 1 -C 20 -alkyl, C 3 -C 20 -cycloalkyl, C 6 -C 20 -aryl, C 7 -C 20 -alkylaryl or C 7 -C 20 -arylalkyl radical, optionally containing heteroatoms belonging to groups 13-17 of the Periodic Table of the Elements; or two adjacent R 3 groups can form a C 4 -C 7 ring optionally containing O, S, N, P or Si atoms, wherein said ring can bear substituents; n and at least one of R 1 , R 2 or R 3 is different from hydrogen.

专利号:EP-1926738-B1
优先权日:2005-09-19
标题:Synthesis of cyclopentadienedithiophene derivatives
发明人：GUIDOTTI SIMONA
权利人:BASELL POLYOLEFINE GMBH
摘要:A process for preparing cyclopentadiene derivatives having formula (I) wherein T1 is selected from the group consisting of oxygen (O), or sulphur (S); R1, R2, R3 and R4, are hydrogen atoms, or hydrocarbon radicals; comprising the following steps: a) reacting a compound of formula (II) with a compound of formula (III) in the presence of a palladium or nickel based catalyst and a base; b) contacting the obtained compound with a carbonylating system; and c) treating the product obtained in step b) with a reducing agent.

专利号:US-6045755-A
优先权日:1997-03-10
标题 :Apparatus and method for combinatorial chemistry synthesis
发明人：LEBL MICHAEL; POKORNY VIT; KRCHNAK VIKTOR
权利人:TREGA BIOSCIENCES INC
摘要:In a first embodiment, this invention includes an integrated robot apparatus for performing combinatorial chemistry synthesis protocols and having interchangeable work-stations, robot arm tools, and reaction vessels and reaction vessel arrays. The work-stations and tools are specialized to perform tasks necessary for the synthesis in a plurality of the reaction vessels grouped in a plurality of the reaction vessel arrays. Preferably, these elements function interchangeably because they have standardized sizes and conformation. The work-stations and tools include those for fluid dispensing or aspirating from individual reaction vessels or from all the reaction vessels in an array simultaneously. The reaction vessels can include, alternatively, stackable, ball-sealed reaction vessels, microtitre-like reaction vessel arrays, arrays of independent reaction vessels, valve-sealed reaction vessels, septum-sealed reaction vessels, and syringe reaction vessels. In alternative embodiments, this invention includes these work-stations, tools, reaction vessels and reaction vessel arrays in various combinations or sub-combinations either for use in partially integrated robots or for manual or standalone use.

专利号:US-7799524-B2
优先权日:2002-10-03
标 题:Substrates for O6-alkylguanina-DNA alkyltransferase
发明人：KINDERMANN MAIK; JOHNSSON KAI; BIERI CHRISTOPH
权利人:ECOLE POLYTECHNIQUE FERDEALE D
摘要:The invention relates to compounds of formula 1 n nwherein R 1 -R 2 is a guanine derivative; X is oxygen or sulfur; R 3 is a heteroaromatic, unsaturated heterocyclyl or an alkynyl group with the double or triple bond connected to CH 2 ; R 4 is a linker; and L is a label, a plurality of same or different labels, a bond connecting R 4 to R 1 forming a cyclic substrate, or a further group —R 3 —CH 2 —X—R 1 -R 2 . The invention relates also to methods of manufacture of such novel AGT substrates, to intermediates useful in the synthesis of such AGT substrates, and to a method of transferring a label from such AGT substrates to O 6 -alkylguanine-DNA alkyltransferase (AGT) fusion proteins comprising proteins of interest.

专利号:US-5916899-A
优先权日:1996-10-18
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.