CAS: 1623-93-4; Biphenyl-4-Sulfonyl Chloride

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3406-84-6 13610-11-2 65685-01-0

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CAS号2113-68-0 联苯-4-磺酸 | CAS号92-67-1 4-氨基联苯 | CAS号92-66-0 4-溴联苯 | CAS号92-52-4 联苯 | CAS号111711-79-6 5-ethoxy-1-(4-p... | CAS号109135-65-1 N,4-diphenylben... | CAS号111711-84-3 1-(4-phenylphen... | CAS号92-52-4 联苯 | CAS号92-94-4 对三联苯 | CAS号135-70-6 对四联苯 | CAS号613-33-2 4,4'-二甲基联苯 | CAS号28952-41-2 1-methyl-4-(4-p... | CAS号19813-90-2 联苯-4-硫醇 | CAS号17064-45-8 2-联苯苯并噁唑

联苯置于氯磺酸,氯化亚砜,N,N-二甲基甲酰胺体系中,用 氯仿 用作溶剂,化学反应 3.5H,反应生成对联苯磺酰氯
参考文献:1-取代-吲哚-2-羧酸作为选择性 Mcl-1 抑制剂的基于片段的设计,合成和生物学评价
标题:1-取代-吲哚-2-羧酸作为选择性 Mcl-1 抑制剂的基于片段的设计,合成和生物学评价
摘要:基于已知的选择性 Mcl-1 抑制剂 6-氯-3-(3-(4-氯-3,5-二甲基苯氧基)丙基)-1H-吲哚-2-羧酸,我们采用基于片段的方法获得延伸到 Bh3 凹槽 P1 口袋的新分子,然后表现出对 Mcl-1 的结合选择性,而不是 Bcl-2 蛋白.在我们从母体分子中解构出 1H-吲哚-2-羧酸后,根据 X 射线鉴定的母体分子的结合模式,在 1 位取代了苯磺酰基以采用优选的几何形状来访问 P1 口袋晶体学.在分子生长以占据 P1 口袋的过程中,配体结合的自由能 (δg) 与非氢重原子数 (Hac) 之间保持线性关系.最后,我们不仅得到了化合物 12 的 7.对 Mcl-1 的选择性比 Bcl-2(ki = 3.6 µm)高 5 倍(荧光偏振的 Ki = 0.48 µm),但也提供了证据表明 P1 口袋的额外占用对 Mcl-1 比对 Bcl-更有利2 结合,对 Mcl-1 抑制的贡献大于对
Doi:10.1002/ardp.201600251

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-10125226-B2
优先权日:2013-06-05
标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils
发明人：FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR
权利人:MEXICANO INST PETROL
摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-3441538-A
优先权日:1965-08-04
标题 :Boron trifluoride - hydrogen fluoride catalyzed synthesis of poly(aromatic ketone) and poly(aromatic sulfone) polymers
发明人：MARKS BARNARD M
权利人:DU PONT