CAS: 160434-49-1; 3-Bromo-4-Fluorocinnamic Acid

相似化合物

923266-17-5 202865-71-2 744240-66-2

上下游产品

malonic acid 3-bromo-4-fluorobenzaldehyde ethyl 3-(3-bromo-4-fluorophenyl)acrylate 3-(3-bromo-4-fluorophenyl)acryloyl chloride

丙二酸,3-溴-4-氟苯甲醛置于哌啶,吡啶体系中,化学反应 3.0H,以3.3 G的收率获得3-溴-4-氟苯乙烯酸
参考文献:4,5-Dihydro-1H-Pyrazole Derivative Or Salts Thereof,And Pharmaceutical Composition Comprising Same
标题:4,5-Dihydro-1H-Pyrazole Derivative Or Salts Thereof,And Pharmaceutical Composition Comprising Same
摘要:本发明提供了一种4,5-二氢-1H-吡唑烷衍生物或其药用可接受盐,以及其制备方法和包含该衍生物的药物组合物.4,5-二氢-1H-吡唑烷衍生物或其药用可接受盐有效增加lxr转录活性,因此可以有效地用于预防或治疗胆固醇代谢功能障碍,如胆固醇结石,高脂血症或冠状动脉粥样硬化.

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6989384-B2
优先权日:2000-06-14
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：HUA YE; LUU HIEP THE; CHAN FORA P; JOHNSON JR THEODORE O; REICH SIEGFRIED HEINZ; SKALITZKY DONALD JAMES; YANG YI; HENDRICKSON THOMAS F; CHU SHAO SONG; EASTMAN BRIAN WALTER
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.