CAS: 15121-89-8; (E)-Ethyl 4-Oxo-4-Phenylbut-2-Enoate

该化合物是一种有机化合物,其特点是其独特的结构,包括一个与一个苯基组和一个氯酮功能组的中间体,该化合物一般是无色的,可粉黄的液体,以其令人愉快的,果味的气味闻闻而闻名,在乙醇和乙醚等有机溶剂中溶解,但由于其疏水性,水溶解性有限.乙基(2E)-4-oxo-4-苯基-2-丁酸酯经常用于有机合成,并可作为生产各种药品和农用化学品的一个中间体.该化合物的再活动受到碳基组的存在的影响,使其易受到核分裂性攻击,从而可能导致进一步的化学变异.安全数据表明,与许多有机化合物一样,应谨慎处理,因为如吸入或浸入,可能会对健康造成危害.适当的储存和处理程序对于确保实验室和工业环境中的安全至关重要.

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统一分类与标签REACH注册ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

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合成工艺路线路线简述

    📜Ethyl 4-Hydroxy-4-Phenylbut-2-Ynoate置于三乙烯二胺体系中,用 二甲基亚砜 用作溶剂,化学反应 4.0H,以72%的收率获得反-3-苯甲酰丙烯酸乙酯
    参考文献:电子不足的炔丙基醇向电子烯的碱催化立体选择性异构化
    标题:电子不足的炔丙基醇向电子烯的碱催化立体选择性异构化
    摘要:我们已经开发出高度立体选择性的方法,可以在温和的条件下(ewg =吸电子基团)将缺电子的炔丙醇异构化为e-烯酮.在我们筛选的弱碱中,发现催化(10-20 Mol%)1,4-二氮杂双环[2.2.2]辛烷(dabco)在大多数情况下有效.当底物与酰胺缀合时,乙酸钠的添加催化了异构化.
    Doi:10.1021/jo060304P

    海关参考信息

    专利信息


    专利号:HU-P0900712-A2
    优先权日:2009-11-13
    标题 :New methods and intermediers for the synthesis of ace-inhibitor

    专利号:CN-107513015-B
    优先权日:2017-07-07
    标题 :A kind of method for preparing 3-benzoyl ethyl acrylate from enalapril intermediate synthesis mother liquor

    专利号:US-10633329-B2
    优先权日:2016-11-17
    标题 :Method for preparing lisinopril intermediate
    发明人：WANG SONGQING; DONG PENG; ZHENG YANG; LI QUANJUN
    权利人:ZHEJIANG HUAHAI PHARM CO LTD; ZHEJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO LTD; ZHEJIANG HUAHAI LICHENG PHARMACEUTICALS CO LTD; ZHEIJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO LTD
    摘要:A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N 2 -[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N 6 -trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.

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    主要参考文献

    参考标题:Tert- Butyl Iodide Mediated Reductive Fischer Indolization Of Conjugated Hydrazones
    作者:Yuta Ito,Masafumi Ueda,Norihiko Takeda,Okiko Miyata |发布日期:2016.2.18
    摘要:Available N‐aryl Conjugated Hydrazones With Tert‐butyl Iodide Has Been Developed. In This Reaction, Tert‐butyl Iodide Is Used As Anhydrous Hi Source, And The Generated Hi Acts As A Brønsted Acid And A Reducing Agent. This Operationally Simple Method Allows Access To Various Indole Derivatives. Furthermore, The Procedure Can Be Applied To The Synthesis Of Biologically Active Compounds.

    合成参考文献


    摘要:Li, W.; Liu, X. H.; Feng, X. M., Science of Synthesis Knowledge Updates, (2021) 1, 11.
    摘要:Li, W.; Liu, X. H.; Feng, X. M., Science of Synthesis Knowledge Updates, (2021) 1, 18.
    摘要:Li, W.; Liu, X. H.; Feng, X. M., Science of Synthesis Knowledge Updates, (2021) 1, 54.
    摘要:Li, W.; Liu, X. H.; Feng, X. M., Science of Synthesis Knowledge Updates, (2021) 1, 34.
    摘要:Wirth, T.; Singh, F. V., Science of Synthesis Knowledge Updates, (2017) 1, 419.
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