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📜3-环丁烯砜置于n-溴代丁二酰亚胺(Nbs)体系中,用 甲醇 用作溶剂,化学反应生成3,4-二溴环丁砜
参考文献:富含环sp3的顺式-β-烷氧基磺酰氯的非对映选择性合成
标题:富含环sp3的顺式-β-烷氧基磺酰氯的非对映选择性合成
摘要:摘要 据报道,由环烯烃和醇三步合成β-烷氧基取代的脂环族磺酰氯.对于具有各种空间和电子特性的一系列基材,研究了该方法的范围.作为单一顺式-非对映异构体,以一百克规模获得标题化合物,总收率高达52%. 据报道,由环烯烃和醇三步合成β-烷氧基取代的脂环族磺酰氯.对于具有各种空间和电子特性的一系列基材,研究了该方法的范围.作为单一顺式-非对映异构体,以一百克规模获得标题化合物,总收率高达52%.
Doi:10.1055/s-0037-1611277

专利信息

专利号:US-4656289-A
优先权日:1984-10-25
标 题 :1,3-dibenzyl-4-halohexahydro-1H-thieno[3,4-d]imidazol-2(3H)-one intermediates
发明人：BATES HANS A; ROSENBLUM STUART
权利人:RES FOUNDATION OF STATE UNIV O
摘要:Novel synthetic routes to (3aα,6aα)-1,3-dibenzyl hexahydro-1H-thieno[3,4-d]imidazol-2(3H)-one 5,5-dioxide, a known intermediate in the synthesis of biotin are provided. n A novel synthetic route from this intermediate to biotin is also disclosed.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.