CAS: 15016-42-9; 2-Vinylphenylboronic Acid

该化合物是一种多用途的boronic酸衍生物,经常用于铃木-米亚乌拉交错反应,这是形成有机合成中碳-碳联系的一种关键方法,其乙烯基组可增强反应性,使与丙烯或乙烯卤化物的有效结合能够产生苯乙烯衍生物,该化合物因其稳定性和与各种反应条件的兼容性,在制药和材料科学研究中特别宝贵.它也是合成聚合物和功能化芳香化合物的一个有用的中间体.碱酸会确保选择性反应性,而乙烯基组可提供进一步的衍生潜力,使其成为先进的合成应用中有价值的建筑块.

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合成工艺路线路线简述

    📜2-Vinylphenylboronic Acid Pinacol Ester置于盐酸,Sodium Periodate体系中,用 四氢呋喃 用作溶剂,化学反应 12.0H,反应生成2-乙烯苯硼酸
    参考文献:Bromo-Boronolactonization Of Olefins1
    标题:Bromo-Boronolactonization Of Olefins1
    摘要:Exposure Of A Variety Of Mono-And Disubstituted Ortho-Alkenylarylboronic Acids To Nbs In Thf/ H2O Under Neutral Conditions Affords Bromo-Boronolactones,In Some Instances,With Exceptional Regiocontrol. The Adducts,Analogous To Those Formed By Carboxylic Acids,Are Shown To Be Useful Synthetic Intermediates.
    Doi:10.1021/jo015838Z

    海关参考信息

    专利信息


    专利号:US-8110642-B2
    优先权日:2006-05-08
    标 题:Synthesis of vinylphenylpyridine and living anionic polymerization
    发明人:LEE JAE-SUK; KANG NAM-GOO
    权利人:LEE JAE-SUK; KANG NAM-GOO; KWANGJU INST SCI & TECH
    摘要:Provided are a vinyl-biphenylpyridine monomer and a polymer thereof. More particularly, the present invention provides a vinyl-biphenylpyridine monomer having a side chain of pyridine or phenylpyridine as a functional group, a homopolymer of which molecular weight and molecular weight distribution are controlled using the monomer, and a block copolymer of which molecular structure and molecular weight are controlled to facilitate synthesis of an organic metal complex. Accordingly, the present invention provides a vinyl-biphenylpyridine monomer and a polymer thereof which are effectively used as nano and optical functional materials.

    专利号:US-2023212216-A1
    优先权日:2019-12-20
    标 题:Synthesis of lactone derivatives and their use in the modification of proteins
    发明人:MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
    权利人:GENIE BIOTECH UK LTD
    摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

    专利号:US-10273329-B2
    优先权日:2016-03-11
    标 题 :Organic semiconductor polymer
    发明人:FANG LEI; LEE JONGBOK; AL-HASHIMI MOHAMMED
    权利人:FANG LEI; LEE JONGBOK; AL HASHIMI MOHAMMED
    摘要:The organic semiconductor polymers relates to the synthesis of a carbazole-based ladder polymer. The synthesis of the ladder polymer includes forming a precursor conjugated polymer by Suzuki step growth polymerization of 2,7-dibromocarbazole with 1,4-dibromo-2,5-divinylbenzene, followed by end capping with 2-bromostyrene and 2-vinyl-phenylboronic acid. Then, the pendent vinyl groups are closed by ring-closing olefin metathesis to obtain the ladder polymer.

    专利号:AU-2020409711-A1
    优先权日:2019-12-20
    标题 :Synthesis of lactone derivatives and their use in the modification of proteins

    专利号:EP-4076533-A1
    优先权日:2019-12-20
    标 题:Synthesis of lactone derivatives and their use in the modification of proteins

    专利号:CA-3164962-A1
    优先权日:2019-12-20
    标题 :Synthesis of lactone derivatives and their use in the modification of proteins

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    合成参考文献


    参考文献:10.1055/s-0041-1737776
    摘要:New Fluorescent BN-PAHs. Synfacts. 2022 Jan 18;18(02):0147. doi: 10.1055/s-0041-1737776.
    参考文献:10.1007/978-3-030-99728-1_6
    摘要:Sunilbhai CA, Alam MS, Sadasivuni KK, Ansari JR. SPR Assisted Diabetes Detection. 2022. In: Springer Series on Bio- and Neurosystems.
    参考文献:10.1007/s43939-024-00111-8
    摘要:Baishya G, Parasar B, Limboo M, Kumar R, Dutta A, Hussain A, Phukan MM, Saikia D. Advancements in nanocomposite hydrogels: a comprehensive review of biomedical applications. Discov Mater. 2024 Aug 28;4(1). doi: 10.1007/s43939-024-00111-8.
    参考文献:10.1007/s00216-010-3998-8
    摘要:Cakal C, Ferrance JP, Landers JP, Caglar P. Development of a micro-total analysis system (μ-TAS) for the determination of catecholamines. Analytical and Bioanalytical Chemistry. 2010 Aug 03;398(5):1909–17. doi: 10.1007/s00216-010-3998-8.
    参考文献:10.1016/j.talanta.2010.04.033
    摘要:He J, Liu Z, Ren L, Liu Y, Dou P, Qian K, Chen HY. On-line coupling of in-tube boronate affinity solid phase microextraction with high performance liquid chromatography-electrospray ionization tandem mass spectrometry for the determination of cis-diol biomolecules. Talanta. 2010 Jun 30;82(1):270–6. doi: 10.1016/j.talanta.2010.04.033.
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