CAS: 14044-63-4; But-3-Yn-1-Amine

相似化合物

88211-50-1 149990-27-2 149965-78-6

上下游产品

CAS号10451-00-0 homopropargylazide | CAS号72486-09-0 丁-3-炔-1-基甲磺酸酯 | CAS号927-74-2 3-丁炔-1-醇 | CAS号110167-07-2 N-(triphenylpho... | CAS号1066-26-8 乙炔化钠,二甲苯溶液 | CAS号2576-47-8 2-溴乙胺氢溴酸盐 | CAS号88211-44-3 氨基甲基化试剂A | CAS号106-96-7 溴代丙炔 | CAS号74-86-2 乙炔 | CAS号111097-54-2 2-Pyrimidinamin... | CAS号107301-61-1 N-benzylbut-3-y... | CAS号88211-50-1 3-丁炔-1-胺盐酸盐 | CAS号149990-27-2 N-B°C-丁炔-4-胺 | CAS号810681-62-0 2H-Indol-2-one,... | CAS号40504-78-7 2-(but-3-ynylam...

📜3-丁炔基甲烷磺酸酯置于ammonium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 3.0H,反应生成1-氨基-3-丁炔
参考文献:高炔丙胺(一种新的灭活剂基序)选择性抑制牛血浆胺氧化酶
标题:高炔丙胺(一种新的灭活剂基序)选择性抑制牛血浆胺氧化酶
摘要:已知炔丙胺和活化的烯丙胺会使醌依赖性血浆胺氧化酶失活,这可能是通过 α,β-不饱和醛周转产物的活性位点修饰来实现的.尽管高炔丙胺 (1-Amino-3-Butyne,1) 作为基于机制的抑制剂是一种非显而易见的候选物,但发现 1 是一种异常有效的时间和浓度依赖性的牛血浆胺氧化酶 (Bpao) 不可逆灭活剂,表现出30 分钟 Ic(50) 2.9 Microm置于30 摄氏度 ([bpao] = 1.2 Microm).变性失活酶保留的辅因子氧化还原活性表明失活 1 涉及在酶变性后逆转的辅因子修饰或活性位点残基的修饰.因为 1 的失活可能涉及反应性 2 的酶烷基化,制备了 1,醛 3 的 3-丁缩醛转换产物的 3-丁二烯醛 (3) 互变异构体,发现它可以使 Bpao 失活,但仅在高浓度下.此外,虽然巯基乙醇的存在减弱了 3 的抑制作用,但没有观测到对 1 的这种保护.制备了其转换应直接导致
Doi:10.1021/ja049568O

专利信息

专利号:US-7652137-B2
优先权日:2003-03-06
标 题:Synthesis of 5 substituted 7-azaindoles and 7-azaindolines
发明人：GRACZYK PIOTR PAWEL; KHAN AFZAL; BHATIA GURPREET SINGH
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.

专利号:US-7259277-B2
优先权日:2003-07-25
标题 :Advanced route for the synthesis of cPLA2 inhibitors
发明人：WU YANZHONG; RAVEENDRATH PANOLIL
权利人:WYETH CORP
摘要:A process for making a compound of formula (I) n nin which process the compound HC≡C—(CH 2 ) n —NH 2 is reacted with the compound R 1 —SO 2 Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of formulan n nto produce the compound of formula (I), and compounds produced by the process of this invention. The terms R 1 , R 2 , R 3 , R 4 and n have the definitions set forth in the specification.

专利号:US-8071718-B2
优先权日:2004-12-22
标题:Selective radiolabeling of biomolecules
发明人：PADILLA DE JESUS OMAYRA LIZ; KOVACS ERNEST WILLIAM; GLASER MATTHIAS EBERHARD; ARSTAD ERIK; SYUD FAISAL AHMED
权利人:PADILLA DE JESUS OMAYRA LIZ; KOVACS ERNEST WILLIAM; GLASER MATTHIAS EBERHARD; ARSTAD ERIK; SYUD FAISAL AHMED; GEN ELECTRIC
摘要:Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.

专利号:US-2012196989-A1
优先权日:2005-02-11
标题:Synthesis of homopolymers and block copolymers
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.

专利号:US-7582771-B2
优先权日:2003-09-03
标题:Process for the synthesis of cPLA2 inhibitors
发明人：DEHNHARDT CHRISTOPH M; MEGATI SREENIVASULU; MICHALAK RONALD S; RAVEENDRANATH PANOLIL; REN JIANXIN; WU CHARLES C; WU YANGZHONG
权利人:WYETH CORP
摘要:A process for making the compound of formula (I) n nwherein Ac represents acetate; X represents O or CH 2 ; Y represents C 1 -C 6 alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF 3 , OCF 3 , OH, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, NH 2 , N(C 1 -C 6 alkyl) 2 , NH(C 1 -C 6 alkyl), NC(O)—(C 1 C 6 alkyl), and NO 2 . In his process, a compound of formula (II)n n nis reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).

专利号:US-9376400-B2
优先权日:2005-06-08
标 题:Process for the synthesis of triazoles
发明人：CHEN SHILI; LOU RONGLIANG; WU YUSHENG; ZHOU JIACHENG; HANSELMANN ROGER
权利人:MELINTA THERAPEUTICS INC
摘要:The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.